Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study

Basit Öğe Kaydı
dc.authoridErsoy, Yuksel/0000-0002-8035-4532
dc.authoridChen, Ruoling/0000-0002-3033-8753
dc.authorwosidchen, ronghe/K-8584-2012
dc.authorwosidErsoy, Yuksel/S-7503-2016
dc.contributor.authorMacWalter, RS
dc.contributor.authorWong, SYS
dc.contributor.authorWong, KYK
dc.contributor.authorStewart, G
dc.contributor.authorFraser, CG
dc.contributor.authorFraser, HW
dc.contributor.authorErsoy, Y
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Purpose-The purpose of this study was to investigate renal function as a long-term predictor of mortality in patients hospitalized for acute stroke. Methods-This was a cohort study done in a Scottish tertiary teaching hospital. Participants included 2042 (993 male) unselected consecutive stroke patients (mean age, 73 years) admitted to hospital within 48 hours of stroke between 1988 and 1994. Follow-up was up to 7 years. Main outcome measure was all-cause mortality. Results-The total number of deaths at the end of follow-up was 1026. Most subjects (1512) had creatinine < 124 mumol/L. The mean calculated creatinine clearance was 54.8 mL/min (SD, 23 mL/min). Renal function indexes were analyzed by quartiles with Cox proportional-hazards model. Stroke survivors had higher calculated creatinine clearance and lower serum creatinine, urea, and ratios of urea to creatinine. Calculated creatinine clearance greater than or equal to51.27 mL/min significantly predicted better long-term survival in these stroke patients even after adjustment for confounders (age, neurological score, ischemic heart disease, hypertension, smoking, and diuretic use). Similarly, creatinine greater than or equal to119 mumol/L [relative risk (RR), 1.59; 95% confidence interval (CI), 1.32 to 1.92], urea 6.8 to 8.9 mmol/L (RR, 1.34; 95% CI, 1.09 to 1.65) or greater than or equal to9 mmol/L (RR, 1.74; 95% CI, 1.42 to 2.13), and ratio of urea to creatinine greater than or equal to0.08573 mmol/mumol (RR, 1.24; 95% CI, 1.03 to 1.50) remained significant predictors of mortality after adjustment for confounders. Conclusions-After acute stroke, patients with reduced admission calculated creatinine clearance, raised serum creatinine and urea concentrations (even within conventional reference intervals), and raised ratio of urea to creatinine had a higher mortality risk. This finding may be used to stratify risk and target interventions, eg, the use of angiotensin-converting enzyme inhibitors.en_US
dc.identifier.doi10.1161/01.STR.0000016344.49819.F7
dc.identifier.endpage1635en_US
dc.identifier.issn0039-2499
dc.identifier.issn1524-4628
dc.identifier.issue6en_US
dc.identifier.pmid12053003en_US
dc.identifier.scopus2-s2.0-0036278176en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1630en_US
dc.identifier.urihttps://doi.org/10.1161/01.STR.0000016344.49819.F7
dc.identifier.urihttps://hdl.handle.net/11616/93397
dc.identifier.volume33en_US
dc.identifier.wosWOS:000176164300047en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofStrokeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcerebrovascular disordersen_US
dc.subjectcreatinineen_US
dc.subjectkidney function testsen_US
dc.subjectmortalityen_US
dc.subjectprognosisen_US
dc.subjectrenal disease, end-stageen_US
dc.subjectstrokeen_US
dc.subjectureaen_US
dc.titleDoes renal dysfunction predict mortality after acute stroke? A 7-year follow-up studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu