Effect of COVID-19 Pandemic on Patients Who Have Undergone Liver Transplantation Because of Hepatocellular Carcinoma

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dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridSaritas, Hasan/0000-0001-7558-8812
dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridTamer, Murat/0000-0001-9142-1844
dc.authoridBAGCI, NAZLICAN/0000-0001-8914-5465
dc.authoridaloun, ali/0000-0002-3548-6536
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidince, volkan/M-7325-2017
dc.contributor.authorAkbulut, Sami
dc.contributor.authorBagci, Nazlican
dc.contributor.authorAkyuz, Musap
dc.contributor.authorGarzali, Ibrahim Umar
dc.contributor.authorSaritas, Hasan
dc.contributor.authorTamer, Murat
dc.contributor.authorInce, Volkan
dc.date.accessioned2024-08-04T20:53:41Z
dc.date.available2024-08-04T20:53:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim. Many clinical studies have shown that the COVID-19 case fatality rate is higher in older patients, those with comorbidities, those with immunosuppressive conditions, and those who stay in the intensive care unit. This study aims to evaluate the clinical outcomes of 66 liver transplant (LT) patients with primary liver cancer who were exposed to COVID-19 infection.Methods. Demographic and clinical data of 66 patients with primary liver cancer (hepatocellu-lar carcinoma = 64, hepatoblastoma = 1, cholangiocarcinoma = 1) who underwent LT in our institute and were exposed to COVID-19 infection between March 2020 and November 2021 were analyzed in this cross-sectional study. The following data of the patients were recorded: age, sex, body mass index (kg/m2), blood group, underlying primary liver disease, smoking, tumor characteristics, post-transplant immunosuppressive agents, COVID-19 symptoms, hospi-talization, intensive care unit stay, intubation, and other clinical features. Results. There were 55 (83.3%) male and 11 (16.7%) female patients, with a median age of 58 years. Sixty-four patients were exposed to COVID-19 only once, whereas the remaining 2 patients were exposed 2 and 4 times, respectively. After exposure to COVID-19, it was deter-mined that 37 patients used antiviral drugs, 25 were hospitalized, 9 were followed in the inten-sive care unit, and 3 were intubated. One intubated patient was under hospital follow-up because of biliary complications before exposure to COVID-19, and this patient died from sepsis. Conclusion. The low mortality rate of LT patients with primary liver cancer exposed to COVID-19 infection can be attributed to background immunosuppression that prevents cytokine storm. However, it is appropriate to support this study with multicenter studies to make strong comments on this issue.en_US
dc.identifier.doi10.1016/j.transproceed.2023.01.038
dc.identifier.endpage1230en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid37137762en_US
dc.identifier.scopus2-s2.0-85154029934en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1226en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2023.01.038
dc.identifier.urihttps://hdl.handle.net/11616/101326
dc.identifier.volume55en_US
dc.identifier.wosWOS:001035795600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSars-Cov-2en_US
dc.titleEffect of COVID-19 Pandemic on Patients Who Have Undergone Liver Transplantation Because of Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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