The effect of caffeic acid phenetyl ester on ischemia - reperfusion injury in comparison with resveratrol in rat ovaries
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
GORM:Gynecology Obstetrics & Reproductive Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz (İngilizce): OBJECTİVE: This experimental study was designed to determine the effects of antioxidants resveratrol and caffeic acid phenetyl ester (CAPE) on nitric oxide (NO) production on an in vivo model of ovarian ischemia-reperfusion in rats. MATERIAL AND METHOD: Rats were divided into five equal groups each consisting eight rats: sham operation, ischemia-reperfusion (I/R), I/R plus CAPE, I/R plus resveratrol and ischemia groups. CAPE and resveratrol was administered intraperitoneally before reperfusion. After experimental procedure rats were killed, ovaries were removed and prepared for NO concentrations. RESULTS: NO levels in saline/detorsion group were increased significantly when compared to sham operation and ischemia groups (p<0.05). Pretreatment with CAPE and resveratrol significantly attenuated the increase of NO levels in ovarian tissue in comparison to I/R and ischemia groups (p<0.05). In the resveratrol and CAPE groups NO levels were similar. CONCLUSİON: As adnexal torsion could influence further fertility of a young woman, new techniques to protect the ovary from I/R injury had to be improved. CAPE and resveratrol were natural antioxidants. We concluded that these medications would be useful to protect the ovaries from the I/R damage.
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
GORM:Gynecology Obstetrics & Reproductive Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
1
Künye
Şeyma H., Önder Ç., Yusuf T., Yılmaz Ç., Bülent M., Saim Y. (2005). The effect of caffeic acid phenetyl ester on ischemia - reperfusion injury in comparison with resveratrol in rat ovaries, GORM:Gynecology Obstetrics & Reproductive Medicine, İnönü Üniversitesi, Malatya.
