The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis

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dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authoridARASLI, MEHMET/0000-0002-5931-419X
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.authorwosidaktunç, erol/AAB-4950-2021
dc.contributor.authorAktunc, Erol
dc.contributor.authorKayhan, Basak
dc.contributor.authorArasli, Mehmet
dc.contributor.authorGun, Banu Dogan
dc.contributor.authorBarut, Figen
dc.date.accessioned2024-08-04T20:35:37Z
dc.date.available2024-08-04T20:35:37Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies have demonstrated that statins have immunomodulatory role by effecting different pathways in immune system. In this study, we investigated the effect of atorvastatin and its mechanism on systemic immune response in treatment of trinitrobenzene sulfonic acid (TNBS)-induced colitis mice. We observed that atorvastatin significantly suppressed the severity of TNBS-induced colitis in BALB/c mice. This was manifested in reduced rectal bleeding, decrease in colon length, reduction of histological damage, and improved survival. Concurrently, we investigated the immunomodulatory role of atorvastatin on systemic immune system. We investigated the proinflammatory (IL-1 alpha, IL-6, TNF-alpha), Th1 (IFN-gamma, IL-2), Th2 (IL-4, IL-5, IL-10), and Th17 (IL-17, IL-23) cytokine levels in serum samples of colitis and atorvastatin-administered mice. We discovered that administration of atorvastatin significantly down-regulates systemic TNF-a level and Th17 cytokine levels. Furthermore, atorvastatin treatment switches Th1 type T-cell response toward/to Th2 (IL-4, IL-10) type response.en_US
dc.identifier.doi10.3109/08923973.2011.559475
dc.identifier.endpage675en_US
dc.identifier.issn0892-3973
dc.identifier.issue4en_US
dc.identifier.pmid21428710en_US
dc.identifier.scopus2-s2.0-80755143841en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage667en_US
dc.identifier.urihttps://doi.org/10.3109/08923973.2011.559475
dc.identifier.urihttps://hdl.handle.net/11616/95480
dc.identifier.volume33en_US
dc.identifier.wosWOS:000296643200014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammatory bowel diseasesen_US
dc.subjectstatinen_US
dc.subjectsystemic immune responseen_US
dc.subjectTh1en_US
dc.subjectTh2en_US
dc.subjectTh17en_US
dc.subjectcytokinesen_US
dc.titleThe effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitisen_US
dc.typeArticleen_US

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