Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.contributor.authorElbe, Hulya
dc.contributor.authorGul, Mehmet
dc.contributor.authorCetin, Asli
dc.contributor.authorTaslidere, Elif
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:44:07Z
dc.date.available2024-08-04T20:44:07Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Hepatotoxicity is amajor complication of acetaminophen (APAP), a widely used analgesic and antipyretic drug. Resveratrol (RSV) is a naturally occurring diphenol and it has anticancer, antioxidant, and anti-inflammatory properties. Objectives: In this study, the beneficial effects of RSV on APAP-induced hepatotoxicity was investigated in rats. Materials and methods: Group 1: Ethanol, Group 2: Saline, Group 3: RSV (10 mg/kg/ip), Group 4: APAP (1000 mg/kg/ip/single dose), Group 5: APAP+RSV (20 min after administration of APAP). The rats were sacrificed 24 h after administration of APAP. Light and electron microscopic changes were evaluated. Levels of malondialdehyde (MDA) and glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities were determined in liver tissue. Results: Rats of the ethanol, saline, and RSV groups did not present any histopathological alterations. In the APAP group, we observed vascular congestion, necrosis, inflammation, sinusoidal dilatation, and loss of glycogen content. In the APAP+RSV group, these changes were markedly reduced. iNOS immunostaining showed very weak positive stained hepatocytes the sections of control, saline, and RSV groups. However, in the APAP group, iNOS immunostaining was most evident in pericentral hepatocytes. In the same areas in APAP+RSV group, intensity of iNOS immunostaining decreased. A significant increase in MDA and decreases in GSH level, CAT, and SOD activity indicated that APAP-induced hepatotoxicity was mediated through oxidative stress. Significant beneficial changes were noted in tissue oxidative stress indicators in rats treatedwith RSV. Conclusion: These biochemical, histopathological, and ultrastructural findings revealed that RSV reduced the severity of APAP-induced alterations in liver.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University, Turkey [2012/85]en_US
dc.description.sponsorshipThis study was financially supported by Scientific Research Fund of Inonu University, Turkey [Grant number: 2012/85].en_US
dc.identifier.doi10.1080/01913123.2017.1374313
dc.identifier.endpage48en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue1en_US
dc.identifier.pmid29192844en_US
dc.identifier.scopus2-s2.0-85035750985en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2017.1374313
dc.identifier.urihttps://hdl.handle.net/11616/98043
dc.identifier.volume42en_US
dc.identifier.wosWOS:000429263200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetaminophenen_US
dc.subjecthepatotoxicityen_US
dc.subjectiNOSen_US
dc.subjectresveratrolen_US
dc.titleResveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expressionen_US
dc.typeArticleen_US

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