Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats

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dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorYalcin, Alper
dc.date.accessioned2024-08-04T20:47:04Z
dc.date.available2024-08-04T20:47:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity. Material and methods: Rats were divided into 4 groups as follows: control, benfotiamine (50 mg/kg, oral gavage (o.g.), for 14 days), MTX (MTX 20 mg/kg intraperitoneally (i.p.) on day 1), MTX + benfotiamine (MTX 20 mg/kg (i.p.) on day 1, then 50 mg/kg (o.g.) benfotiamine for 14 days). Liver tissue was used to examine histopathological and immunohistochemical changes. Serum was used to look for oxidative stress markers (total antioxidant status (TAS) and total oxidant status (TOS)). Results: Administration of MTX caused a significant TOS increase and TAS decrease in the serum as compared to the control group. Immunohistochemically, irisin was significantly increased in immunoreactivity in the MTX group as compared to the control group (p < 0.05). Significant histopathological improvement and decrease in serum TOS levels were observed in the MTX + benfotiamine group compared to the MTX group (p < 0.05). In addition, an increase in TAS level and a decrease in irisin immunoreactivity were observed but they were not statistically significant (p > 0.05). Conclusions: Our results showed that MTX caused an increase in the activity of irisin after producing toxicity in the liver. In addition, we found that benfotiamine was effective in preventing damage caused by MTX in the liver.en_US
dc.identifier.doi10.5114/aoms.2018.80002
dc.identifier.endpage211en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue1en_US
dc.identifier.pmid32051725en_US
dc.identifier.scopus2-s2.0-85077751378en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2018.80002
dc.identifier.urihttps://hdl.handle.net/11616/99139
dc.identifier.volume16en_US
dc.identifier.wosWOS:000505030200027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectirisinen_US
dc.subjectliver toxicityen_US
dc.subjectbenfotiamineen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.titleProtective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in ratsen_US
dc.typeArticleen_US

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