Acrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOG

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dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorUremis, Nuray
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorDurhan, Merve
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:54:51Z
dc.date.available2024-08-04T20:54:51Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in fried and baked carbohydrate-rich foods. ACR is regarded as a typical axonal neurotoxin that induces neuropathy. The brain is protected from oxidative damage by vitamin E, which is regarded as the most powerful fat-soluble antioxidant vitamin. This study aimed to reveal the toxic effect of ACR on the development of myelin in the brain at the molecular level and to examine whether Vitamin E has a neuroprotective effect on the harmful effect of ACR. The study was started by dividing 40 pregnant rats into 4 groups and after lactation, the study was continued with offspring rats (females and males offspring rats) from each group. Offspring rats were equally divided into Control, Vitamin E, ACR, ACR + Vitamin E groups. Following the ACR administration, the Water Maze test was applied to evaluate cognitive function. To evaluate the level of demyelination and remyelination, MBP, MAG, and MOG proteins and mRNA levels were performed. In addition, the degeneration of myelin and glial cells was examined by immunohistochemistry and electron microscopic analysis. Analysis results showed that ACR administration decreased gene and protein levels of myelin-related proteins MBP, MAG, and MOG. The findings were confirmed by histopathological, immunohistochemical, and microscopic examinations. The application of vitamin E improved this negative effect of ACR. It has been observed that ACR may play a role in the pathogenesis of myelin-related neurodegenerative diseases by causing demyelination during gestation, lactation, and post-lactation. In addition, it has been understood that vitamin E supports myelination as a strong neuroprotective vitamin against the toxicity caused by ACR. Our research results suggest that acrylamide may play a role in the etiopathogenesis of demyelinating diseases such as multiple sclerosis in humans since fast-food-type nutrition is very common today and people are chronically exposed to acrylamide.en_US
dc.description.sponsorshipInonu University Scientific Research Project Units [TDK-2019-1948]en_US
dc.description.sponsorshipThis study was funded by Inonu University Scientific Research Project Units (Project no: TDK-2019-1948).en_US
dc.identifier.doi10.1007/s11064-023-04053-0
dc.identifier.endpage635en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue3en_US
dc.identifier.pmid37989894en_US
dc.identifier.scopus2-s2.0-85177229195en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-023-04053-0
dc.identifier.urihttps://hdl.handle.net/11616/101680
dc.identifier.volume49en_US
dc.identifier.wosWOS:001106057000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectOffspring raten_US
dc.subjectBrainen_US
dc.subjectNeurodegenerationen_US
dc.subjectMyelinen_US
dc.subjectVitamin Een_US
dc.titleAcrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOGen_US
dc.typeArticleen_US

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