New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies
| dc.contributor.author | Tekin, Suat | |
| dc.date.accessioned | 2019-07-22T07:34:24Z | |
| dc.date.available | 2019-07-22T07:34:24Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L)(2)] and [Pt(L)(2)), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules. The photophysical properties changes were observed after deprotonation of L with CN- via intermolecular charge transfer (ICT). Additionally, as the sensor is a colorimetric and fluorimetric cyanide probe containing active sites such as coumarin-thiazole and imine (CH = N), it showed fast color change from yellow to deep red in the visible region, and yellow fluorescence after CN- addition to the imine bond, in DMSO. The reaction mechanisms of L with CN-, F- and AcO- ions were evaluated using H-1 NMR shifts. The results showed that, the reaction of L with CN- ion was due to the deprotonation and addition mechanisms at the same time. The anti-cancer activity of L and its Pd(II) and Pt(II) complexes were evaluated in vitro using MTT assay on the human cancer lines MCF-7 (human breast adenocarcinoma), LS174T (human colon carcinoma), and LNCAP (human prostate adenocarcinoma). The anticancer effects of L and its complexes, on human cells, were determined by comparing the half maximal inhibitory concentration (IC50) values. The activity results showed that, the Pd(II) complex of L has higher antitumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines. | en_US |
| dc.identifier.citation | Tekin, S. (2018). New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies. Cilt:178, 428-439 ss. | en_US |
| dc.identifier.doi | 10.1016/j.jphotobiol.2017.11.030 | en_US |
| dc.identifier.endpage | 439 | en_US |
| dc.identifier.startpage | 428 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/12814 | |
| dc.identifier.volume | 178 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLAND | en_US |
| dc.relation.ispartof | Journal of photochemıstry and photobıology b-bıology | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Carbonyls M(Co)(6) M | en_US |
| dc.subject | Mıcrowave Irradıatıon | en_US |
| dc.subject | Antımıcrobıal Agents | en_US |
| dc.subject | Antıtumor-Actıvıtıes | en_US |
| dc.subject | Dna Cleavage | en_US |
| dc.subject | Derıvatıves | en_US |
| dc.subject | Cu(Iı) | en_US |
| dc.subject | Antıbacterıal | en_US |
| dc.subject | Pd(Iı) | en_US |
| dc.subject | Nı(Iı) | en_US |
| dc.title | New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies | en_US |
| dc.type | Article | en_US |
