Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats

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dc.authoridKayir, Hakan/0000-0002-6423-4207
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridCelik, Turgay/0000-0003-2787-2485
dc.authoridKAYIR, Hakan/0000-0002-6423-4207
dc.authoridUlusoy, Kemal Gökhan/0000-0003-1786-2945
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidKayir, Hakan/C-1589-2009
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidCelik, Turgay/U-9233-2019
dc.authorwosidKAYIR, Hakan/B-1894-2016
dc.authorwosidUlusoy, Kemal Gökhan/AAQ-1253-2021
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorUzbay, T.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorAkdag, E.
dc.contributor.authorCelik, T.
dc.contributor.authorYararbas, G.
dc.contributor.authorUlusoy, G.
dc.contributor.authorAcet, A.
dc.date.accessioned2024-08-04T20:36:12Z
dc.date.available2024-08-04T20:36:12Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough melatonin has been implicated in several neurophysiological systems, data on the relationship of melatonin with psychosis such as schizophrenia are limited and contradictory. Chronic effects of melatonin on sensorimotor gating deficits have also not been investigated yet. We investigated the neurobehavioral effects of chronic administration of melatonin in pinealectomized (Px) and ovariectomized (Ovx) rats. Px or Ovx or both operations were carried out together to the rats. The control group of rats was sham operated. A sham ovariectomy was carried out to Px rats, and vice versa. Fifth month later, melatonin (5 mg/kg) or vehicle was injected to rats for 28 days. Then, prepulse inhibition (PPI) of acoustic startle reflex, startle amplitude and startle reflex latency was measured. Locomotor activity, accelerod performance measurements, novel object recognition and passive avoidance tests were also evaluated. Px and Px + Ovx rats had impaired PPI compared to control rats. Melatonin reversed the impairments of PPI induced by Px or Px + Ovx. While melatonin treatment had no effect on locomotor activity of control rats, it significantly increased the locomotor activity of Px and Px + Ovx rats. Melatonin treatment (5 mg/kg/day, 28 days) reversed the locomotor hyperactivity caused by Ovx. Accelerod performance, passive avoidance, and object recognition responses of Px, Ovx or Px + Ovx rats were not different from the control group. Our results indicate that chronic melatonin deficiency by reason of Px results in impairment of PPI reflex and replacement of melatonin exerts beneficial effects on the impaired PPI reflex in Px and Ovx rats. Thus, melatonin may be useful in the treatment of some disorders characterized by sensorimotor gating deficits such as schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [105S387, SBAG-3194]en_US
dc.description.sponsorshipThis study was supported by Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 105S387, SBAG-3194). The authors thank Mr. Selami Alan for his technical assistance during the study.en_US
dc.identifier.doi10.1016/j.bbr.2012.10.008
dc.identifier.endpage7en_US
dc.identifier.issn0166-4328
dc.identifier.pmid23078952en_US
dc.identifier.scopus2-s2.0-84869203455en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2012.10.008
dc.identifier.urihttps://hdl.handle.net/11616/95856
dc.identifier.volume239en_US
dc.identifier.wosWOS:000314146600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectPinealectomyen_US
dc.subjectOvariectomyen_US
dc.subjectPrepulse inhibition (PPI)en_US
dc.subjectSchizophreniaen_US
dc.subjectRat(s)en_US
dc.titleChronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized ratsen_US
dc.typeArticleen_US

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