Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridDemir, Mehmet/0000-0001-6990-3337
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidDemir, Mehmet/HLV-7821-2023
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.contributor.authorYilmaz, Umit
dc.contributor.authorTekin, Suat
dc.contributor.authorDemir, Mehmet
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the impact of intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic-pituitary-thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used and divided into three groups including control, sham (vehicle) and FGF21 infused groups (n = 10). Intracerebroventricularly, FGF21 and vehicle groups were infused for 7 days with FGF21 (0.72 mu g/day) and artificial cerebrospinal fluid, respectively. During the experimental period, changes in food intake and body weight were recorded daily. Serum thyroid stimulating hormone (TSH), Triiodothyronine (T3) and thyroxine (T4) levels were measured using ELISA. TRH and uncoupling protein 1 (UCP1) gene expressions were analyzed by using RT-PCR in hypothalamus and adipose tissues, respectively. Chronic infusion of FGF21 significantly increased serum TSH (p < 0.05), T3 (p < 0.05) and T4 (p < 0.001) levels. Additionally, hypothalamic TRH (p < 0.05) and UCP1 gene expressions (p<0.05) in white adipose tissue were found to be higher than in the vehicle and control groups. While FGF21 infusion did not cause a significant change in food consumption, it caused a reduction in the body weight of rats (p < 0.05). Our findings indicate that FGF21 may have an effect on energy metabolism via the HPT axis.en_US
dc.description.sponsorshipResearch Support Unit of Inonu University [2014/16]en_US
dc.description.sponsorshipThis study was supported by the Research Support Unit of Inonu University, Project no: 2014/16.en_US
dc.identifier.doi10.1007/s12576-018-0595-7
dc.identifier.endpage788en_US
dc.identifier.issn1880-6546
dc.identifier.issn1880-6562
dc.identifier.issue6en_US
dc.identifier.pmid29417398en_US
dc.identifier.scopus2-s2.0-85041523110en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage781en_US
dc.identifier.urihttps://doi.org/10.1007/s12576-018-0595-7
dc.identifier.urihttps://hdl.handle.net/11616/98142
dc.identifier.volume68en_US
dc.identifier.wosWOS:000449788000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal of Physiological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFGF21en_US
dc.subjectIntracerebroventricularen_US
dc.subjectThyroid hormonesen_US
dc.subjectUCP1en_US
dc.titleEffects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in ratsen_US
dc.typeArticleen_US

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