Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain

Basit Öğe Kaydı
dc.authoridIrmak, M. Kemal/0000-0002-1903-8303
dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidIrmak, M. Kemal/H-6667-2014
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.contributor.authorIrmak, MK
dc.contributor.authorFadillioglu, E
dc.contributor.authorSogut, S
dc.contributor.authorErdogan, H
dc.contributor.authorGulec, M
dc.contributor.authorOzer, M
dc.contributor.authorYagmurca, M
dc.date.accessioned2024-08-04T20:13:26Z
dc.date.available2024-08-04T20:13:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.descriptionMeeting on Functional Cellular Biochemistry -- NOV, 2002 -- LONDON, ENGLANDen_US
dc.description.abstractOxygen-derived free radicals have been implicated in the pathogenesis of cerebral injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. The purpose of the present study was to investigate the effects of ischaemia and subsequent reperfusion on rat brain and to investigate the effects of two free radical scavengers, CAPE and alpha-tocopherol, on this in vivo model of cerebral injury. Ischaemia was induced by bilateral occlusion of the carotid arteries for 20 min and reperfusion was achieved by releasing the occlusion to restore the circulation for 20 min. Control rats underwent a sham operation. CAPE at 10 mumol kg(-1) or alpha-tocopherol at 25 mumol kg(-1) was administered intraperitoneally before reperfusion. Reperfusion led to significant increase in the activity of xanthine oxidase and higher malondialdehyde levels in the brain. Acute administration of both CAPE and alpha-tocopherol suppressed ischaemia-reperfusion-induced cerebral lipid peroxidation and injury, but CAPE seems to offer a better therapeutic advantage over alpha-tocopherol. Copyright (C) 2003 John Wiley Sons, Ltd.en_US
dc.description.sponsorshipRoyal Soc Meden_US
dc.identifier.doi10.1002/cbf.1024
dc.identifier.endpage289en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue3en_US
dc.identifier.pmid12910483en_US
dc.identifier.scopus2-s2.0-0042734778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1024
dc.identifier.urihttps://hdl.handle.net/11616/93604
dc.identifier.volume21en_US
dc.identifier.wosWOS:000184750200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectreperfusion injuryen_US
dc.subjectfree radicalsen_US
dc.subjectbrainen_US
dc.titleEffects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brainen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu