The possible pathophysiological role of plasma nitric oxide and adrenomedullin in schizophrenia

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridBAĞCI, CAHİT/0000-0001-5211-4366
dc.authoridÇAKMAK, Ecir Ali/0000-0003-2735-2105;
dc.authorwosidZoroglu, Salih/ABD-8029-2020
dc.authorwosidCengiz, Beyhan/F-6044-2011
dc.authorwosidUz, Efkan/B-2943-2016
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidBAĞCI, CAHİT/HPI-0043-2023
dc.authorwosidÇAKMAK, Ecir Ali/HSH-2722-2023
dc.authorwosidzoroglu, suleyman s/B-2077-2012
dc.contributor.authorZoroglu, SS
dc.contributor.authorHerken, H
dc.contributor.authorYürekli, M
dc.contributor.authorUz, E
dc.contributor.authorTutkun, H
dc.contributor.authorSavas, HA
dc.contributor.authorBagci, C
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEvidence is accumulating for a possible role of nitric oxide (NO) in schizophrenia. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain consistent with a role as neurotransmitter. We aimed to examine plasma levels of nitrite (a metabolite of NO) and AM in schizophrenic patients. Eighty-two patients with schizophrenia and 21 healthy control subjects were included in this study. DSM-IV diagnosis of chronic schizophrenia was established on the basis of independent structured clinical interviews and review of records by two qualified psychiatrists which included the Brief Psychiatric Rating Scale (BPRS), The Scale for the Assessment of Negative Symptoms (SANS) and The Scale for the Assessment of Positive Symptoms (SAPS). Total nitrite and AM have been studied in plasma. The mean values of plasma nitrite and AM levels in schizophrenic group were significantly higher than control values, respectively (P = 0.03, P < 0.0001). AM levels of schizophrenic patients were three fold higher than controls. In correlation analyses, there were statistically significant positive correlations between AM level and SAPS-delusion subscale (r = 0.27, P = 0.04); SAPS-bizarre behavior subscale (r = 0.28, P = 0.03) and SAPS-total (r = 0.36, P = 0.005). There is no correlation between total nitrite and AM levels (r = 0.11, P = 0.31). Both NO and AM may have a pathophysiological role in schizophrenia, and clinically symptomatology and prognosis of schizophrenia. This subject needs further study including treatment response and subtypes of schizophrenia. (C) 2002 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.endpage315en_US
dc.identifier.issn0022-3956
dc.identifier.issue5en_US
dc.identifier.pmid12127598en_US
dc.identifier.scopus2-s2.0-0036313848en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://hdl.handle.net/11616/93403
dc.identifier.volume36en_US
dc.identifier.wosWOS:000178254700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectnitric oxideen_US
dc.subjectschizophreniaen_US
dc.subjectclinical symptomsen_US
dc.subjectprognosisen_US
dc.titleThe possible pathophysiological role of plasma nitric oxide and adrenomedullin in schizophreniaen_US
dc.typeArticleen_US

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