Effects of nonsteroidal antiinflammatory drugs on the thiol groups and lipid peroxidation in ethanol-induced oxidative stress

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dc.authorscopusid6603643064
dc.authorscopusid6603430215
dc.authorscopusid7003459703
dc.contributor.authorAktay G.
dc.contributor.authorTozkoparan B.
dc.contributor.authorErtan M.
dc.date.accessioned2024-08-04T20:01:07Z
dc.date.available2024-08-04T20:01:07Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate whether nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (IBU), indomethacin (INDO), aspirin (ASP), and celecoxib (CEL) could enhance the susceptibility the oxidative stress caused by the acute intoxication with ethanol in gastric mucosa, liver and brain of mice. The results showed that only the IBU treatment contribute to the control of the lipid peroxidation (LPO) and thiol group levels in all tissues. However, CEL can be able to increase the susceptibility of gastric mucosa to ethanol-induced oxidative stress like classic NSAIDs. while it has a significant protective effect in brain tissue..en_US
dc.identifier.endpage112en_US
dc.identifier.issn1300-638X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-4644257510en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://hdl.handle.net/11616/91259
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofActa Pharmaceutica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOX-2 inhibitorsen_US
dc.subjectLipid peroxidationen_US
dc.subjectNonsteroidal antiinflammatory drugsen_US
dc.subjectReduced glutathioneen_US
dc.subjectTotal thiol groupsen_US
dc.titleEffects of nonsteroidal antiinflammatory drugs on the thiol groups and lipid peroxidation in ethanol-induced oxidative stressen_US
dc.typeArticleen_US

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