Proven Food-Induced Acute Urticaria and Predictive Factors for Definitive Diagnosis in Childhood

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dc.authoridOzdemir, Cevdet/0000-0002-9284-4520
dc.authoridOrhan, Fazil/0000-0002-4850-932X
dc.authoridCekic, Sukru/0000-0002-9574-1842
dc.authoridHizli Demirkale, Zeynep/0000-0001-6159-9895
dc.authoridCulpan, Hazal Cansu/0000-0001-9244-3818
dc.authoridKiykim, Ayca/0000-0001-5821-3963
dc.authoridYUCEL, Esra/0000-0003-3712-2522
dc.authorwosidErdogan, Mehmet Sarper/AAC-2696-2020
dc.authorwosidOzdemir, Cevdet/X-5856-2018
dc.authorwosidOrhan, Fazil/AAL-6641-2021
dc.authorwosidYücel, Esra/AAT-3250-2020
dc.authorwosidOZDEMIR, ONER/KPB-3723-2024
dc.authorwosidCekic, Sukru/L-1933-2017
dc.authorwosidHizli Demirkale, Zeynep/AAU-4506-2020
dc.contributor.authorAydogan, Metin
dc.contributor.authorTopal, Erdem
dc.contributor.authorUysal, Pinar
dc.contributor.authorAcar, Hazal Cansu
dc.contributor.authorCavkaytar, Ozlem
dc.contributor.authorDemirkale, Zeynep Hizli
dc.contributor.authorAydogmus, Cigdem
dc.date.accessioned2024-08-04T20:49:20Z
dc.date.available2024-08-04T20:49:20Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Urticaria can be the only sign of a food allergy or can be seen together with other signs and symptoms of a food allergy. Objective: To determine the demographic, etiologic, and clinical features of food-induced acute urticaria in childhood. Methods: Patients suspected of food-induced acute urticaria were included in this prospective cross-sectional multicenter study. Results: Two hundred twenty-nine urticaria cases were included in this study. Seventeen patients who did not meet the inclusion criteria of the study were excluded. Of the 212 included cases, 179 (84.4%) were diagnosed with definitive food-induced acute urticaria. The most common foods causing acute urticaria were cow's milk, hen's eggs, and nuts in 56.4, 35.2, and 19% of cases, respectively. The positive predictive value of a history of milk-induced acute urticaria together with a milk-specific IgE >5 kU/L for cow's milk-induced acute urticaria was 92% (95% CI: 81-96%). A history of cow's milk-induced and/or hen's egg-induced acute urticaria was consistent with a definitive diagnosis of food-induced urticaria (Chen's kappa: 0.664 and 0.627 for milk and eggs, respectively). Urticaria activity scores were higher in patients with food-induced acute urticaria (p = 0.002). Conclusion: Cow's milk, hen's eggs, and nuts were the most common allergens in the etiology of childhood food-induced acute urticaria. Although the urticaria activity score provides guidance for diagnosis, an oral food challenge is often essential for the definitive diagnosis of a patient with a history of food-induced acute urticaria.en_US
dc.identifier.doi10.1159/000513267
dc.identifier.endpage614en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue7en_US
dc.identifier.pmid33601370en_US
dc.identifier.scopus2-s2.0-85101734424en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage607en_US
dc.identifier.urihttps://doi.org/10.1159/000513267
dc.identifier.urihttps://hdl.handle.net/11616/99790
dc.identifier.volume182en_US
dc.identifier.wosWOS:000621521200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhooden_US
dc.subjectFood allergyen_US
dc.subjectUrticariaen_US
dc.titleProven Food-Induced Acute Urticaria and Predictive Factors for Definitive Diagnosis in Childhooden_US
dc.typeArticleen_US

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