New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies

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dc.authoridHokelek, Tuncer/0000-0002-8602-4382
dc.authoridAYDINER, BURCU/0000-0003-1823-6217
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKaya, kerem/0000-0002-5736-488X
dc.authoridsahin, omer/0000-0002-1742-6062
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidHokelek, Tuncer/G-6068-2013
dc.authorwosidAYDINER, BURCU/AAB-5359-2019
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidKaya, kerem/V-3794-2017
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidHokelek, Tuncer/JCE-0691-2023
dc.contributor.authorSahin, Omer
dc.contributor.authorOzdemir, Ummuhan Ozmen
dc.contributor.authorSeferoglu, Nurgul
dc.contributor.authorGenc, Zuhal Karagoz
dc.contributor.authorKaya, Kerem
dc.contributor.authorAydiner, Burcu
dc.contributor.authorTekin, Suat
dc.date.accessioned2024-08-04T20:44:07Z
dc.date.available2024-08-04T20:44:07Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L)(2)] and [Pt(L)(2)), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules. The photophysical properties changes were observed after deprotonation of L with CN- via intermolecular charge transfer (ICT). Additionally, as the sensor is a colorimetric and fluorimetric cyanide probe containing active sites such as coumarin-thiazole and imine (CH = N), it showed fast color change from yellow to deep red in the visible region, and yellow fluorescence after CN- addition to the imine bond, in DMSO. The reaction mechanisms of L with CN-, F- and AcO- ions were evaluated using H-1 NMR shifts. The results showed that, the reaction of L with CN- ion was due to the deprotonation and addition mechanisms at the same time. The anti-cancer activity of L and its Pd(II) and Pt(II) complexes were evaluated in vitro using MTT assay on the human cancer lines MCF-7 (human breast adenocarcinoma), LS174T (human colon carcinoma), and LNCAP (human prostate adenocarcinoma). The anticancer effects of L and its complexes, on human cells, were determined by comparing the half maximal inhibitory concentration (IC50) values. The activity results showed that, the Pd(II) complex of L has higher antitumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.en_US
dc.description.sponsorshipTUBITAK [214Z152]; State of Planning Organization [2010K120480]en_US
dc.description.sponsorshipWe thank TUBITAK [Project Grant No: 214Z152) for financial support. We are also thankful to ITU for the use of the Bruker SMART BREEZE CCD diffractometer (purchased under grant No.2010K120480 of the State of Planning Organization).en_US
dc.identifier.doi10.1016/j.jphotobiol.2017.11.030
dc.identifier.endpage439en_US
dc.identifier.issn1011-1344
dc.identifier.issn1873-2682
dc.identifier.pmid29216566en_US
dc.identifier.scopus2-s2.0-85036532894en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2017.11.030
dc.identifier.urihttps://hdl.handle.net/11616/98050
dc.identifier.volume178en_US
dc.identifier.wosWOS:000424727600051en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Photochemistry and Photobiology B-Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchiff baseen_US
dc.subjectCoumarin-thiazoleen_US
dc.subjectFluorescent chemosensoren_US
dc.subjectPlatinum (II) and palladium (II) complexesen_US
dc.subjectAnticancer activityen_US
dc.subjectAnion sensitivityen_US
dc.titleNew platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studiesen_US
dc.typeArticleen_US

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