Therapeutic effect of diasmin-hesperidin in primary dysmenorrhea

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dc.authorscopusid6603116813
dc.authorscopusid6506315065
dc.authorscopusid6602971894
dc.authorscopusid55886237400
dc.contributor.authorKafkasli A.
dc.contributor.authorBuhur A.
dc.contributor.authorBurak F.
dc.contributor.authorTaskin O.
dc.date.accessioned2024-08-04T20:00:56Z
dc.date.available2024-08-04T20:00:56Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To evaluate the effect of Flavinoid fraction; 450 mg Diasmin + 50 mg Hesperidin (DH), a venotrophic drug, in the treatment of the primary dysmenorrhea. Study Design: Thirty women, presenting with moderate (6 of 30, 20%) or severe (24 of 30, 80%) primary dysmenorrhea, were randomly divided into 2 groups. Each group received either DH tid or placebo for three months immediately after the onset of the menstrual flow and then each group was switched to the other regimen for the following three months. Ten point visual analogue scale was used to measure the pain of the patients. Statistical analysis was carried out by using student's t test, and chi square-test. Results: Pain scores were similiar in the placebo and the DH treated groups before treatment (7.5 ± 0.7 and 8.1 ± 0.2 respectively). Pain scores began to decrease one-hour following the DH administration and reduced to the lowest point at the third hour (from 5.5 ± 0.9 to 3.4 ± 0.9, p < 0.05). Satisfactory pain relief was detected in 90% of the patients. Meanwhile, pain scores in the placebo group did not change (7.8 ± 0.1 versus 7.6 ± 0.2, p > 0.05). The severity of the pain returned to pretreatment levels when the patients were switched to placebo. Conclusion: DH may be an effective drug for the treatment of primary dysmenorrhea in patients who can not use nonsteroidal anti-inflammatory drugs.en_US
dc.identifier.endpage110en_US
dc.identifier.issn1300-0438
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0030860458en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://hdl.handle.net/11616/91128
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJinekoloji ve Obstetri Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiasminen_US
dc.subjecthesperidineen_US
dc.subjectprimary dysmenorrheaen_US
dc.titleTherapeutic effect of diasmin-hesperidin in primary dysmenorrheaen_US
dc.title.alternativePrimer dizmenore tedavisinde diasmin-hesperidin etkisien_US
dc.typeArticleen_US

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