The vaginal microbiota composition of women undergoing assisted reproduction: a prospective cohort study

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dc.authoridUnver, Tuba/0000-0002-8655-2716
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridDogan, Berat/0000-0003-4810-1970
dc.authorwosidUnver, Tuba/ABI-6440-2020
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidDogan, Berat/AAJ-7288-2020
dc.contributor.authorKaraer, A.
dc.contributor.authorDogan, B.
dc.contributor.authorGunal, S.
dc.contributor.authorTuncay, G.
dc.contributor.authorDuz, S. Arda
dc.contributor.authorUnver, T.
dc.contributor.authorTecellioglu, N.
dc.date.accessioned2024-08-04T20:50:20Z
dc.date.available2024-08-04T20:50:20Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To evaluate the impact of vaginal microbiota on pregnancy outcomes in women undergoing assisted reproduction. Design A prospective cohort study. Setting A university-based assisted reproductive technology (ART) centre. Population 223 women undergoing ART treatment. Methods Prior to embryo transfer, vaginal samples were collected from the posterior fornix. Vaginal microbiota identification was carried out using next-generation sequencing and categorised according to the V3-V4 hypervariable region in the 16S rRNA gene region. Main outcome measures ART clinical outcomes (implantation, clinical pregnancy rates and live birth rates). Results The live birth rate in women with community state type (CST)-I (39%) was higher than that in women with CST-III (21.5%) but the difference was not statistically significant (P = 0.052). The relative abundance of Lactobacillus was lower in women who failed to become pregnant (NP group) (67.71%) than in women who became pregnant (PR group) (79.72%). However, this difference was not statistically significant (P = 0.06). In the NP group, the relative abundance of Streptococcus (7.81%) and Gardnerella (9.40%) was higher than that in the PR group (relative abundance of Streptococcus and Gardnerella was 2.28% and 5.56%, respectively). The abundance of Streptococcus was found to be statistically significantly different between the two study groups (P = 0.014). Linear discriminant analysis (LDA) further validated that Streptococcus had the highest contribution (LDA score >4.0) to the difference between these two groups. Conclusions Streptococcus has the highest contribution to the distinction between the PR and NP groups. Tweetable abstract A relatively high abundance of Streptococcus in the vaginal microbiota may be associated with a lower ART success rate.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [215S738]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), project number 215S738.en_US
dc.identifier.doi10.1111/1471-0528.16782
dc.identifier.endpage2109en_US
dc.identifier.issn1470-0328
dc.identifier.issn1471-0528
dc.identifier.issue13en_US
dc.identifier.pmid34053157en_US
dc.identifier.scopus2-s2.0-85108286431en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2101en_US
dc.identifier.urihttps://doi.org/10.1111/1471-0528.16782
dc.identifier.urihttps://hdl.handle.net/11616/99995
dc.identifier.volume128en_US
dc.identifier.wosWOS:000663674100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBjog-An International Journal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectassisted reproductive technologyen_US
dc.subjectinfertilityen_US
dc.subjectmicrobiotaen_US
dc.subjectpregnancy outcomeen_US
dc.subjectvaginal microbiomeen_US
dc.titleThe vaginal microbiota composition of women undergoing assisted reproduction: a prospective cohort studyen_US
dc.typeArticleen_US

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