Trimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat model

Basit Öğe Kaydı
dc.authoridÇelik, Hüseyin Tuğrul/0000-0001-9442-3431
dc.authoridOzcan, Muhammet Fuat/0000-0002-9809-7204
dc.authoridHEKIMOGLU, RUMEYSA HEKIMOGLU/0000-0003-4300-7213
dc.authorwosidÇelik, Hüseyin Tuğrul/JJF-5327-2023
dc.authorwosidOzcan, Muhammet Fuat/AEY-7440-2022
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.authorwosidener, kemal/GQZ-7438-2022
dc.contributor.authorOzcan, M. F.
dc.contributor.authorHekimoglu, E. R.
dc.contributor.authorEner, K.
dc.contributor.authorNamuslu, M.
dc.contributor.authorAltintas, R.
dc.contributor.authorCelik, H. T.
dc.contributor.authorAkbulut, Z.
dc.date.accessioned2024-08-04T20:43:00Z
dc.date.available2024-08-04T20:43:00Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effects of trimetazidine (TMZ), as an antioxidant agent, on streptozotocin (STZ)-induced diabetic rats. A total of 50 male Sprague Dawley rats were randomly classified into five groups as follows: Group 1 (control), Group 2 (STZ-induced diabetic rats), Group 3 (STZ-induced diabetic rats treated orally with 1cc/day isotonic saline), Group 4 (diabetic rats treated orally with 10mg/kg/day TMZ) and Group 5 (diabetic rats treated orally with 20mg/kg/day TMZ). After 8weeks, orchiectomy was carried out. Histopathological and electron microscopic examinations were performed in all groups. In groups 1 and 5, the structural and ultra-structural findings of the testicular tissue and spermatogenesis were found normal. In groups 2, 3 and 4, similar results were obtained in terms of the impaired testicular architecture and degeneration of spermatogenesis. The administration of an optimal dose of TMZ protects against the harmful effects of diabetes mellitus on spermatogenesis in rats. TMZ therapy can be used to maintain normal spermatogenesis in diabetic rats.en_US
dc.identifier.doi10.1111/and.12780
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10en_US
dc.identifier.pmid28261829en_US
dc.identifier.scopus2-s2.0-85014453739en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.12780
dc.identifier.urihttps://hdl.handle.net/11616/97718
dc.identifier.volume49en_US
dc.identifier.wosWOS:000414965200023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdiabetesen_US
dc.subjectratsen_US
dc.subjectspermatogenesisen_US
dc.subjectstreptozotocinen_US
dc.subjecttrimetazidineen_US
dc.titleTrimetazidine has protective effects on spermatogenesis in a streptozotocin-induced diabetic rat modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu