Anticancer, antimicrobial and antiparasitical activities of copper(I) complexes based on N-heterocyclic carbene (NHC) ligands bearing aryl substituents

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dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridAL NASR, IBRAHIM/0000-0003-4690-1050
dc.authoridKhan, Tariq Ayub/0000-0001-6184-5929
dc.authorwosidTouj, Nedra/AAM-2982-2021
dc.authorwosidNasr, Ibrahim Al/AFP-8105-2022
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidsulaiman, ibrahim/GQZ-6901-2022
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidTouj, Nedra/G-6828-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.contributor.authorTouj, Nedra
dc.contributor.authorAl Nasr, Ibrahim S.
dc.contributor.authorKoko, Waleed S.
dc.contributor.authorKhan, Tariq A.
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorYasar, Sedat
dc.contributor.authorMansour, Lamjed
dc.date.accessioned2024-08-04T20:49:04Z
dc.date.available2024-08-04T20:49:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These NHC precursors were metallated with Cu2O and CuI in acetone and water under reflux to give novel copper(I) complexes. The structures of these benzimidazolium salts and copper(I) complexes were characterized on the basis of elemental analysis, H-1 NMR, C-13 NMR, IR and LC-MS spectroscopic techniques. The (NHC)Cu(I) complexes 3-4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites and against Vero cell line in vitro. The synthesized copper NHC carbene complex 4b (1,3-bis(2,3,4,5,6-pentamdthylbenzyl)-2,3-dihydro-1H-benzo[d]imidazol-2-yl)copper(I) chloride) was the most active against MCF7 cancer cells (half growth Inhibition Concentrations (IC50) = 0.3 mu g mL(-1)), as well as the most potent antimicrobial against E. coli (inhibition zone (IZ) = 23.3 mm), MRSA (IZ = 25.5 mm) and C. albicans (IZ = 28.5 mm) besides its antileishmanial activities against L. major promastigotes and amastigotes (IC50 < 0.04 mu g mL(-1)). Compound 4c (1,3-bis(4-(tert-butyl)benzyl)-2,3-dihydro-1H-benzo[d]imida-zol-2-yl)copper(II) bromide) is the most potent anticancer against MDA-MB-231 cancer cells IC50 = 0.4 mu g mL(-1)). Compound 4e (5,6-dimethyl-1,3-bis(2,4,6-trimethylbenzyl)-2,3-dihydro-1H-benzo[d]imidazol-2-yl)copper(I) chloride) is the best suitable antitoxoplasmal drug candidate due to its SI of 16.5. These candidates need further study to identify mode of action and drug standardization.en_US
dc.description.sponsorshipKing Saud University, Riyadh Saudi Arabia [RSP2020/75]en_US
dc.description.sponsorshipThis work was funded by the Research Supporting Project (RSP2020/75), King Saud University, Riyadh Saudi Arabia.en_US
dc.identifier.doi10.1080/00958972.2020.1836359
dc.identifier.endpage2905en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue20-22en_US
dc.identifier.scopus2-s2.0-85095746633en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2889en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2020.1836359
dc.identifier.urihttps://hdl.handle.net/11616/99618
dc.identifier.volume73en_US
dc.identifier.wosWOS:000587549100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject(NHC)Cu(I) Complexesen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectbiological activityen_US
dc.titleAnticancer, antimicrobial and antiparasitical activities of copper(I) complexes based on N-heterocyclic carbene (NHC) ligands bearing aryl substituentsen_US
dc.typeArticleen_US

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