Prunus armeniaca L (apricot) protects rat testes from detrimental effects of low-dose x-rays

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.contributor.authorUgras, Murat Y.
dc.contributor.authorKurus, Meltem
dc.contributor.authorAtes, Burhan
dc.contributor.authorSoylemez, Haluk
dc.contributor.authorOtlu, Ali
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:32:23Z
dc.date.available2024-08-04T20:32:23Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractExposure to low x-ray doses damages the spermatozoa, mainly by late-onset (ie, after 3 months) oxidative stress. Antioxidants ameliorate oxidation and prevent tissue damage. Prunus armeniaca L (apricot), rich in carotenoids and vitamins, is a potent natural antioxidant. We hypothesized that an apricot-rich diet might ameliorate the detrimental effects of low-dose x-rays on testis tissue. A 20% apricot diet was composed isoenergetically to the regular rodent diet. The total phenolic content, reducing power, and antioxidant capacity of both diets were determined. Sprague-Dawley rats received apricot-rich diets before and after x-ray exposure. Regular diets were given to controls. Rats were exposed to 0.2 Gy x-rays at the eighth week and were euthanized at the 20th postexposure week. Testicular oxidative status was determined by tissue thiobarbituric acid-reactive substances, reduced glutathione, superoxide dismutase, and catalase activities. For histologic evaluation, qualitative and quantitative microscopic determinations were performed, and Leydig and Sertoli cell counts and Johnsen scores were measured. The control diet group had significant testicular oxidative stress and mild tissue deterioration. Leydig and Sertoli cell counts, tubule diameters, and Johnsen scores were significantly decreased in the exposure groups. Apricot-rich diet significantly ameliorated the oxidative status and prevented the damage in tubular histology. The protective effects were prominent when the diet was maintained throughout the time course and were partially protected when the diet was initiated after exposure. The natural antioxidant activity of apricot ameliorates the delayed detrimental effects of low-dose irradiation on testis tissue. The high total antioxidant capacity of the apricot deserves further investigation. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.nutres.2010.03.001
dc.identifier.endpage208en_US
dc.identifier.issn0271-5317
dc.identifier.issn1879-0739
dc.identifier.issue3en_US
dc.identifier.pmid20417881en_US
dc.identifier.scopus2-s2.0-77952245205en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.1016/j.nutres.2010.03.001
dc.identifier.urihttps://hdl.handle.net/11616/95033
dc.identifier.volume30en_US
dc.identifier.wosWOS:000277529000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRaten_US
dc.subjectAntioxidantsen_US
dc.subjectApricoten_US
dc.subjectIrradiationen_US
dc.subjectLow doseen_US
dc.subjectX-rayen_US
dc.subjectOxidative stressen_US
dc.subjectTestisen_US
dc.titlePrunus armeniaca L (apricot) protects rat testes from detrimental effects of low-dose x-raysen_US
dc.typeArticleen_US

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