Histological assessment of liver and stomach damage caused by pyridazinone derivative antidepressant agents

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authoridUSLU, HARUN/0000-0001-8827-8557
dc.authoridOzdemir, Zenyep/0000-0003-4559-2305
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.authorwosidUSLU, HARUN/P-3681-2019
dc.authorwosidOzdemir, Zenyep/AAJ-6384-2020
dc.contributor.authorOzdemir, Zeynep
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorTaslidere, Elif
dc.contributor.authorVardi, Nigar
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorUslu, Harun
dc.date.accessioned2024-08-04T20:50:52Z
dc.date.available2024-08-04T20:50:52Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDepression is a serious psychological disorder that affects a significant population. We investigated the antidepressant activities of four pyridazinone derivatives that contain the hydrazide moiety using the forced swimming test (FST). The compounds tested exhibited good antidepressant activity compared to duloxetine. The most promising compound was compound 2, which reduced the duration of immobility during FST. The toxic effects of the four compounds on the histomorphology of the liver and stomach tissue also was evaluated.en_US
dc.description.sponsorshipInonu University Scientific Researches Unit [2011/80]en_US
dc.description.sponsorshipThis project was supported by Inonu University Scientific Researches Unit [Project no. 2011/80].en_US
dc.identifier.doi10.1080/10520295.2021.1999499
dc.identifier.endpage362en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid34842474en_US
dc.identifier.scopus2-s2.0-85120041827en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1999499
dc.identifier.urihttps://hdl.handle.net/11616/100330
dc.identifier.volume97en_US
dc.identifier.wosWOS:000723469500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressanten_US
dc.subjecthistopathologyen_US
dc.subjectliveren_US
dc.subjectmiceen_US
dc.subjectpyridazinoneen_US
dc.subjectstomachen_US
dc.subjectswimming testen_US
dc.titleHistological assessment of liver and stomach damage caused by pyridazinone derivative antidepressant agentsen_US
dc.typeArticleen_US

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