Serum and ascites fluid cytokine levels in patients with chronic heart failure
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Cardiologica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective - Cytokines that are capable of modulating cardiovascular function were reported to be elevated in patients with advanced heart failure. We evaluated the diagnostic importance of cytokines both in the serum and ascites. Material and methods - We determined serum and ascites fluid TNF-alpha, IL-1 beta, IL-6, IL-8, and soluble IL-2 receptor levels in 14 patients with congestive heart failure (group I) and in 15 patients with chronic liver disease (group 2). Results - Ascites fluid IL-8 and soluble IL-2 receptor levels were found to be significantly elevated in group I when compared with group 2 (p = 0.014 and p = 0.005). There were no statistical differences in serum TNF-alpha, IL-1 beta, IL-6, IL-8, and soluble IL-2 receptor levels and ascites fluid TNF-alpha, 1L- I (IL-1 beta, and IL-6 Ievels. Ascites fluid/serum IL- I (IL-1 beta and IL-8 ratio was lower in group 1 when compared with group 2 (p = 0.001 and p = 0.005). Ascites fluid/serum IL-2 and IL-6 ratio was higher in group I when compared with group 2 (p = 0.035 and p = 0.025). Conclusion - Cytokine levels in ascites fluid, but not in serum, are important in congestive heart failure. Ascites fluid/serum cytokine level ratios were detected to be more conclusive and valid in the diagnosis work-up of ascites aetiology.
Açıklama
Anahtar Kelimeler
heart failure, ascites, cytokines
Kaynak
Acta Cardiologica
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
56
Sayı
4
