Serum and ascites fluid cytokine levels in patients with chronic heart failure

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dc.authoridHilmioğlu, Fatih/0000-0002-6440-5686
dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authorwosidSari, Ramazan/C-2868-2016
dc.authorwosidSari, Funda/C-7068-2016
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidHilmioğlu, Fatih/AAJ-4437-2021
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.contributor.authorSari, R
dc.contributor.authorYildirim, B
dc.contributor.authorSevinc, A
dc.contributor.authorBahceci, F
dc.contributor.authorOzdemir, R
dc.contributor.authorHilmioglu, F
dc.date.accessioned2024-08-04T21:01:08Z
dc.date.available2024-08-04T21:01:08Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective - Cytokines that are capable of modulating cardiovascular function were reported to be elevated in patients with advanced heart failure. We evaluated the diagnostic importance of cytokines both in the serum and ascites. Material and methods - We determined serum and ascites fluid TNF-alpha, IL-1 beta, IL-6, IL-8, and soluble IL-2 receptor levels in 14 patients with congestive heart failure (group I) and in 15 patients with chronic liver disease (group 2). Results - Ascites fluid IL-8 and soluble IL-2 receptor levels were found to be significantly elevated in group I when compared with group 2 (p = 0.014 and p = 0.005). There were no statistical differences in serum TNF-alpha, IL-1 beta, IL-6, IL-8, and soluble IL-2 receptor levels and ascites fluid TNF-alpha, 1L- I (IL-1 beta, and IL-6 Ievels. Ascites fluid/serum IL- I (IL-1 beta and IL-8 ratio was lower in group 1 when compared with group 2 (p = 0.001 and p = 0.005). Ascites fluid/serum IL-2 and IL-6 ratio was higher in group I when compared with group 2 (p = 0.035 and p = 0.025). Conclusion - Cytokine levels in ascites fluid, but not in serum, are important in congestive heart failure. Ascites fluid/serum cytokine level ratios were detected to be more conclusive and valid in the diagnosis work-up of ascites aetiology.en_US
dc.identifier.doi10.2143/AC.56.4.2005647
dc.identifier.endpage223en_US
dc.identifier.issn0001-5385
dc.identifier.issue4en_US
dc.identifier.pmid11573826en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.2143/AC.56.4.2005647
dc.identifier.urihttps://hdl.handle.net/11616/104106
dc.identifier.volume56en_US
dc.identifier.wosWOS:000171087900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectheart failureen_US
dc.subjectascitesen_US
dc.subjectcytokinesen_US
dc.titleSerum and ascites fluid cytokine levels in patients with chronic heart failureen_US
dc.typeArticleen_US

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