Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior

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dc.contributor.authorYildiz, Sevler
dc.contributor.authorEmir, Burcu Sirlier
dc.contributor.authorKilicaslan, Asli Kazgan
dc.contributor.authorKurt, Osman
dc.contributor.authorUgur, Kerim
dc.contributor.authorSehlikoglu, Seyma
dc.contributor.authorAtmaca, Murad
dc.date.accessioned2026-04-04T13:33:32Z
dc.date.available2026-04-04T13:33:32Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThe role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.
dc.identifier.doi10.1080/14789949.2024.2429663
dc.identifier.endpage292
dc.identifier.issn1478-9949
dc.identifier.issn1478-9957
dc.identifier.issue3
dc.identifier.orcid0000-0002-0312-0476
dc.identifier.orcid0000-0003-4164-3611
dc.identifier.orcid0000-0002-9512-713X
dc.identifier.orcid0000-0002-3389-5790
dc.identifier.orcid0000-0002-3131-6564
dc.identifier.scopus2-s2.0-85210144245
dc.identifier.scopusqualityQ3
dc.identifier.startpage275
dc.identifier.urihttps://doi.org/10.1080/14789949.2024.2429663
dc.identifier.urihttps://hdl.handle.net/11616/109229
dc.identifier.volume36
dc.identifier.wosWOS:001363763600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofJournal of Forensic Psychiatry & Psychology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectPsychotic disorder
dc.subjectSIRI
dc.subjectSII
dc.subjectinflammation
dc.subjectHDL
dc.subjecthemogram
dc.titleInflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior
dc.typeArticle

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