Relation between serum Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 levels, clinical status and growth parameters in prepubertal cystic fibrosis patients

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dc.authoridcokugras, Haluk Cezmi/0000-0002-0086-3936
dc.authoridOzen, Metehan/0000-0003-4088-3103
dc.authorwosidÇokuğraş, Haluk C/D-2598-2019
dc.authorwosidOzen, Metehan/X-2705-2018
dc.authorwosidOzen, Metehan/E-2610-2016
dc.contributor.authorOzen, M
dc.contributor.authorCokugras, H
dc.contributor.authorOzen, N
dc.contributor.authorCamcioglu, Y
dc.contributor.authorAkcakaya, N
dc.date.accessioned2024-08-04T20:30:48Z
dc.date.available2024-08-04T20:30:48Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: This study aims to determine the relation between anabolic hormones, Insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3), growth parameters, and clinical status in prepubertal cystic fibrosis (CF) patients. This prospective study comprises age/sex-matched control subjects and was set in a tertiary care teaching hospital. Methods: Serum concentrations of IGF-I and IGFBP-3 were measured in 37 CF and 23 healthy subjects, whose mean ages were 5.02 +/- 3.06 and 5.27 +/- 2.82, respectively. The results were analyzed in relation to body mass index standard deviation scores (BMISD), height standard deviation scores (HSD), growth velocity standard deviation scores (GVSD), and clinical status assessed by Shwachman scores and pulmonary function parameters. Results: Serum IGFBP-3 of CF patients showed significantly lower concentrations than healthy subjects (2457 vs. 3249 ng/mL) (P < 0.05), whereas IGF-I levels did not (123.35 vs. 149.8 ng/mL). There was significant positive correlation between IGF-I and IGFBP-3 with HSD (r = 0.62; r = 0.79) and BMISD (r = 0.39; r = 0.50). The pulmonary function tests in 14 CF subjects were not statistically worse than in nine healthy cases. The mean HSD (-0.67, SD 1.06) and BMISD (-0.28, SD 0.71) of CF patients were not significantly lower than those of healthy subjects (-0.02, SD 0.86 and 0.03, SD 0.49), respectively. Conclusion: Decreased serum IGF-I and IGFBP-3 levels may reflect growth retardation in CF. IGFBP-3 seems like a more sensitive parameter than IGF-I for growth monitoring in this study. Growth parameters of Turkish prepubertal CF patients are not markedly below national standards. Different genetic backgrounds of relevant populations certainly play an important role for the variable clinical course.en_US
dc.identifier.doi10.1111/j.1442-200x.2004.01925.x
dc.identifier.endpage435en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue4en_US
dc.identifier.pmid15310308en_US
dc.identifier.scopus2-s2.0-4344640661en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200x.2004.01925.x
dc.identifier.urihttps://hdl.handle.net/11616/94538
dc.identifier.volume46en_US
dc.identifier.wosWOS:000222982100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcystic fibrosisen_US
dc.subjectgrowth parametersen_US
dc.subjectIGF-Ien_US
dc.subjectIGFBP-3en_US
dc.subjectprepubertyen_US
dc.titleRelation between serum Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 levels, clinical status and growth parameters in prepubertal cystic fibrosis patientsen_US
dc.typeArticleen_US

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