Evaluation of the Effect of Honey-Containing Chitosan/Hyaluronic Acid Hydrogels on Wound Healing

Basit Öğe Kaydı
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridARISOY, SEMA/0000-0003-2798-1884
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.authorwosidARISOY, SEMA/V-1458-2017
dc.contributor.authorSalva, Emine
dc.contributor.authorAkdag, Ahmet Enes
dc.contributor.authorAlan, Saadet
dc.contributor.authorArisoy, Sema
dc.contributor.authorAkbuga, Fatma Julide
dc.date.accessioned2024-08-04T20:54:52Z
dc.date.available2024-08-04T20:54:52Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe 3D polymeric network structure of hydrogels imitates the extracellular matrix, thereby facilitating cell growth and differentiation. In the current study, chitosan/hyaluronic acid/honey coacervate hydrogels were produced without any chemicals or crosslinking agents and investigated for their wound-healing abilities. Chitosan/hyaluronic acid/honey hydrogels were characterized by FTIR, SEM, and rheology analysis. Moreover, their water content, water uptake capacities, and porosity were investigated. In FT-IR spectra, it was discovered that the characteristic band placement of chitosan with hyaluronic acid changed upon interacting with honey. The porosity of the honey-containing hydrogels (12%) decreased compared to those without honey (17%). Additionally, the water-uptake capacity of honey-containing hydrogels slightly decreased. Also, it was observed that hydrogels' viscosity increased with the increased hyaluronic acid amount and decreased with the amount of honey. The adhesion and proliferation of fibroblast cells on the surface of hydrogel formulations were highest in honey-containing hydrogels (144%). In in vivo studies, wound healing was accelerated by honey addition. It has been demonstrated for the first time that honey-loaded chitosan-hyaluronic acid hydrogels, prepared without the use of toxic covalent crosslinkers, have potential for use in wound healing applications.en_US
dc.identifier.doi10.3390/gels9110856
dc.identifier.issn2310-2861
dc.identifier.issue11en_US
dc.identifier.pmid37998945en_US
dc.identifier.scopus2-s2.0-85178089578en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/gels9110856
dc.identifier.urihttps://hdl.handle.net/11616/101692
dc.identifier.volume9en_US
dc.identifier.wosWOS:001120261700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofGelsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchitosanen_US
dc.subjecthoneyen_US
dc.subjecthyaluronic aciden_US
dc.subjectwound healingen_US
dc.subjecthydrogelen_US
dc.subjecttissue engineeringen_US
dc.titleEvaluation of the Effect of Honey-Containing Chitosan/Hyaluronic Acid Hydrogels on Wound Healingen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu