Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats

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dc.authoridKilic, Talat/0000-0001-8125-9062
dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151
dc.authoridErmis, Hilal/0000-0002-1764-9098;
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorIraz, M
dc.contributor.authorErdogan, H
dc.contributor.authorKotuk, M
dc.contributor.authorYagmurca, M
dc.contributor.authorKilic, T
dc.contributor.authorErmis, H
dc.contributor.authorFadillioglu, E
dc.date.accessioned2024-08-04T20:15:15Z
dc.date.available2024-08-04T20:15:15Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxidative stress has been implicated in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been studied for prevention and treatment of the disease in animals and humans. We therefore examined whether Ginkgo biloba (Gb), a flavonoid-rich antioxidant, inhibits bleomycin-induced lung fibrosis in rats. Male Spraque-Dawley rats were given a single dose of bleomycin (2.5 mg/kg, intratracheally) in pulmonary fibrosis groups and saline in controls. First dose of Gb was given a day before the bleomycin injection and continued until sacrifice. At day 14, fibrotic changes in lung were estimated to occur by Aschoft's criteria and lung hydroxyproline content. Bleomycin challenge provoked severe pulmonary fibrosis with marked increase in hydroxyproline content of lung tissue and typical histological findings, which is prevented by Gb. Hydroxyproline level was significantly higher (13.51 +/- 0.87 mg/g dried tissue) in bleomycin treated rats than controls (9.2 +/- 1.33), and its level was remained to the control levels (7.38 +/- 0.76) in rats treated with prophylactic Gb. On the other hand, bleomycin injection significantly reduced activities of glutathione peroxidase, superoxide dismutase and catalase in lung tissue which is prevented by Gb. Also, bleomycin injection resulted in a marked increase of malondialdehyde and nirite level which is attenuated by Gb. The data suggest that Gb has a potent antioxidant activity in the model of bleomycin-induced lung fibrosis in rats, and therefore has a potent antifibrotic activity against bleomycin-induced lung fibrosis model in rats. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2005.12.009
dc.identifier.endpage316en_US
dc.identifier.issn1043-6618
dc.identifier.issn1096-1186
dc.identifier.issue3en_US
dc.identifier.pmid16459098en_US
dc.identifier.scopus2-s2.0-32644463355en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2005.12.009
dc.identifier.urihttps://hdl.handle.net/11616/94273
dc.identifier.volume53en_US
dc.identifier.wosWOS:000236072800016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbleomycinen_US
dc.subjectlung fibrosisen_US
dc.subjectGinkgo bilobaen_US
dc.titleGinkgo biloba inhibits bleomycin-induced lung fibrosis in ratsen_US
dc.typeArticleen_US

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