The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo p dioxin toxicity in female reproductive system in rats

Basit Öğe Kaydı
dc.authoridTR124840en_US
dc.authoridTR102040en_US
dc.authoridTR52354en_US
dc.authoridTR103979en_US
dc.authoridTR153390en_US
dc.contributor.authorMelekoğlu, Rauf
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorÇetin, Aslı
dc.contributor.authorBaşak, Neşe
dc.contributor.authorÇelik, Ebru
dc.date.accessioned2017-04-17T11:04:17Z
dc.date.available2017-04-17T11:04:17Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.en_US
dc.identifier.citationMelekoğlu, R. Çiftçi, O. Çetin, A. Başak, N. Çelik, E. (2016). The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo p dioxin toxicity in female reproductive system in rats . Acta Cir Bras. 31 (8) - 557-563.en_US
dc.identifier.endpage563en_US
dc.identifier.issn1678-2674
dc.identifier.issue8en_US
dc.identifier.startpage557en_US
dc.identifier.urihttp://dx.doi.org/10.1590/S0102-865020160080000009
dc.identifier.urihttps://hdl.handle.net/11616/6673
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherActa Cir Bras.en_US
dc.relation.ispartofActa Cir Bras.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTetrachlorodibenzodioxinen_US
dc.subjectOxidative Stressen_US
dc.subjectLeukotriene Antagonistsen_US
dc.subjectOvaryen_US
dc.subjectUterusen_US
dc.titleThe beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo p dioxin toxicity in female reproductive system in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
1.68 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Sağlık Bilimleri Enstitüsü Diğer Yayınlar Koleksiyonu