A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridMinareci, Yagmur/0000-0003-1420-9318
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidMinareci, Yagmur/AAJ-7114-2021
dc.contributor.authorCelik, Ebru
dc.contributor.authorCelik, Onder
dc.contributor.authorKumbak, Banu
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorKaraer, Abdullah
dc.date.accessioned2024-08-04T20:37:36Z
dc.date.available2024-08-04T20:37:36Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo determine whether concentrations of oxidative stress markers of follicular fluid and serum are different in GnRH agonist protocol from GnRH antagonist protocol. This was a cross-sectional study. Eighty-four women undergoing controlled ovarian stimulation with either GnRH agonist (n = 39) or GnRH antagonist protocols (n = 45) for IVF/ICSI treatment were assigned by a physician. Blood was obtained at the time of oocyte retrieval, and follicular fluid (FF) from the mature follicles of each ovary was centrifuged and frozen until analysis. Malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), hydroxyl proline (OH-P), sodium oxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) and xanthine oxidase (XO) were assessed in the serum and follicular fluid of each participants. The mean serum concentrations of GSH-Px, GSH and MDA were lower in the GnRH antagonist group compared to GnRH agonist group, but mean serum SOD was higher in the GnRH antagonist group. The mean follicular SOD, ADA and NO were higher in GnRH antagonist group than GnRH agonist group. The IVF/ICSI outcomes were similar in both groups. GnRH antagonist protocol is associated with increased oxidative stress. The relation of GnRH analogues with oxidative stress and its implication in follicular growth needs to be addressed in further studies.en_US
dc.identifier.doi10.1007/s10815-012-9843-6
dc.identifier.endpage1183en_US
dc.identifier.issn1058-0468
dc.identifier.issue11en_US
dc.identifier.pmid22886458en_US
dc.identifier.scopus2-s2.0-84878364772en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1175en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-012-9843-6
dc.identifier.urihttps://hdl.handle.net/11616/96074
dc.identifier.volume29en_US
dc.identifier.wosWOS:000312071400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectGnRH antagonisten_US
dc.subjectGnRH agonisten_US
dc.subjectIVF/ICSIen_US
dc.titleA comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cyclesen_US
dc.typeArticleen_US

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