Melatonin: A review of its potential functions and effects on neurological diseases

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridGunata, Mehmet/0000-0001-6905-4259
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidGunata, Mehmet/AAW-2738-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorGunata, M.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorAcet, H. A.
dc.date.accessioned2024-08-04T20:46:57Z
dc.date.available2024-08-04T20:46:57Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. - The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared. Conclusions. - In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. (C) 2019 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.neurol.2019.07.025
dc.identifier.endpage165en_US
dc.identifier.issn0035-3787
dc.identifier.issn2213-0004
dc.identifier.issue3en_US
dc.identifier.pmid31718830en_US
dc.identifier.scopus2-s2.0-85075455664en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1016/j.neurol.2019.07.025
dc.identifier.urihttps://hdl.handle.net/11616/99070
dc.identifier.volume176en_US
dc.identifier.wosWOS:000522098500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofRevue Neurologiqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectParkinson's diseaseen_US
dc.subjectMultiple sclerosisen_US
dc.subjectEpilepsyen_US
dc.titleMelatonin: A review of its potential functions and effects on neurological diseasesen_US
dc.typeReview Articleen_US

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