Experimental stress-induced changes in trace element levels of various tissues in rats

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dc.authorwosidMENGİ, MURAT/Q-7048-2017
dc.contributor.authorKarakoc, Y
dc.contributor.authorYurdakos, E
dc.contributor.authorGulyasar, T
dc.contributor.authorMengi, M
dc.contributor.authorBarutcu, UB
dc.date.accessioned2024-08-04T20:13:13Z
dc.date.available2024-08-04T20:13:13Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we investigated the effects of acute and chronic immobilization stress on the Zn, Cu, and Fe levels of the temporal lobe, brain stem, spleen, and liver tissues in rats. The animals in the acute stress group were put in the cages, one time only for 120 min. For the chronic stress groups (2h and 4h), the rats were kept in the cages daily for 2 and 4 h, respectively, for 5 consecutive days. Controls and immobilized rats were decapitated, and then tissue samples were taken. Zn, Cu, and Fe levels in the temporal lobe, brain stem, spleen, and liver were measured by flame atomic absorption spectrophotometer. Our results showed that acute immobilization stress causes endogenous Zn and Cu release from the brain tissues. In the 2h chronic stress group, Fe levels markedly increase in the temporal lobe and brain stem whereas they decrease in the spleen and liver. In the 4h chronic stress group, Fe levels increase in the temporal lobe and brain stem while Zn and Cu levels increase in the spleen and liver. In the acute and chronic immobilization stress groups, mobilization of Zn and Cu can be related to the induction of metallothionein (MT) in the liver and spleen but not in the brain. On the other hand, excess Fe in the temporal lobe and brain stem causes us to believe think that the brain iron transport proteins may be involved, and enhanced, by immobilization stress.en_US
dc.identifier.doi10.1002/jtra.10023
dc.identifier.endpage60en_US
dc.identifier.issn0896-548X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0037258412en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1002/jtra.10023
dc.identifier.urihttps://hdl.handle.net/11616/93479
dc.identifier.volume16en_US
dc.identifier.wosWOS:000180724200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofJournal of Trace Elements in Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectimmobilizationen_US
dc.subjectrestraint stressen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.subjectironen_US
dc.subjectraten_US
dc.titleExperimental stress-induced changes in trace element levels of various tissues in ratsen_US
dc.typeArticleen_US

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