Effect of risperidone on auditory event-related potentials in patients with chronic schizophrenia

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dc.authorscopusid6601957780
dc.authorscopusid7003374400
dc.authorscopusid6506898918
dc.authorscopusid7006083811
dc.authorscopusid7006785766
dc.contributor.authorÖzişik H.I.
dc.contributor.authorÖzcan Y.
dc.contributor.authorKizkin S.
dc.contributor.authorÜnal S.
dc.contributor.authorÖzcan C.
dc.date.accessioned2024-08-04T20:00:37Z
dc.date.available2024-08-04T20:00:37Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Cognitive deficits are major aspect and cause of disability in schizophrenia. Several neuropsychological studies have reported significant effects of atypical neuroleptics on cognitive functioning in patients with schizophrenia. Event-related potentials are objective assessments of human information processing, and provide a reliable method for evaluating the effects of psychotropic drugs. Methods: The study sample consisted of 7 subjects. They were outpatients at the Department of Psychiatry, İnönü University Hospital. The patients were diagnosed as having schizophrenia according to the DSM-IV on the basis of a structured psychiatric interview. The subjects were treated with risperidone. In order to examine the effects of risperidone on cognitive impairment in schizophrenia, event-related potentials (ERPs) were recorded before and after 6 weeks treatment ERPs were recorded using a standard oddball paradigm. The amplitudes and latencies of P300 component were measured in ERPs for target stimuli in the oddball task. Results: P300 latencies in Fz, Cz and Pz regions and amplitudes in Fz and Cz regions significantly decreased with risperidone treatment. Conclusion: These findings suggest that risperidone may speed up the information processing in schizophrenic patients.en_US
dc.identifier.endpage17en_US
dc.identifier.issn1017-7833
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-18344374511en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://hdl.handle.net/11616/90857
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofKlinik Psikofarmakoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEvent-related potentialsen_US
dc.subjectP300en_US
dc.subjectRisperidoneen_US
dc.subjectSchizophreniaen_US
dc.subjectTherapyen_US
dc.titleEffect of risperidone on auditory event-related potentials in patients with chronic schizophreniaen_US
dc.title.alternativeKronik şizofreni hastalarinda i?şitsel olaya i?lişkin potansiyeller üzerine risperidonun etkisien_US
dc.typeArticleen_US

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