Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorBag, Harika Gozde Gozukara
dc.date.accessioned2024-08-04T20:45:24Z
dc.date.available2024-08-04T20:45:24Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundThere are many studies with different results that examine the association between Catechol-O-MethylTransferase (COMT) gene single-nucleotide polymorphisms (SNPs) and schizophrenia. In this study, the aim was to conduct a meta-analysis to achieve a pooled effect size of the association between COMT gene rs165599 SNP and schizophrenia. MethodsOdds ratio (OR) was used as an effect size to determine the association between schizophrenia and the SNP. The pooled ORs were achieved under four different genetic models. When the heterogeneity among studies was high the DerSimonian-Laird random-effects model, otherwise the Mantel-Haenszel fixed-effects model was used. Publication bias was evaluated by Egger's test. ResultsUnder different genetic models no statistically significant association was found between rs165599 SNP and schizophrenia by meta-analyses consist of 20 independent studies. There was high heterogeneity among studies, for the possible reason the population differences, although the subgroup analyzes reduced the heterogeneity, no association was obtained. However, the sex-specific estimation of the females showed that to be a G allele carrier is a risk factor for schizophrenia (OR=1.366 [95% confidence interval=1.094-1.706]) compared to AA homozygous. ConclusionThe COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia.en_US
dc.identifier.doi10.1002/mgg3.468
dc.identifier.endpage854en_US
dc.identifier.issn2324-9269
dc.identifier.issue5en_US
dc.identifier.pmid30165727en_US
dc.identifier.scopus2-s2.0-85052810396en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage845en_US
dc.identifier.urihttps://doi.org/10.1002/mgg3.468
dc.identifier.urihttps://hdl.handle.net/11616/98455
dc.identifier.volume6en_US
dc.identifier.wosWOS:000445851700017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMolecular Genetics & Genomic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOMTen_US
dc.subjectmeta-analysisen_US
dc.subjectodds ratioen_US
dc.subjectschizophreniaen_US
dc.subjectSNPen_US
dc.titleAssociation between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studiesen_US
dc.typeArticleen_US

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