To compare aneuploidy rates between ICSI and IVF Cases

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dc.authoridBozkurt, Mehmet Recep/0000-0003-0673-4454;
dc.authorwosidBozkurt, Mehmet Recep/A-4167-2016
dc.authorwosidCaliskan, Eray/HTR-8541-2023
dc.contributor.authorSahin, L.
dc.contributor.authorBozkurt, M.
dc.contributor.authorSahin, H.
dc.contributor.authorGurel, A.
dc.contributor.authorCaliskan, E.
dc.date.accessioned2024-08-04T20:43:58Z
dc.date.available2024-08-04T20:43:58Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Intracytoplasmic sperm injection (ICSI) currently helps many couples with male infertility. However, ICSI procedure may cause asynchronous sperm decondensation. This could introduce a risk for aneuploidy. The ICSI technique also could cause damage to the second meiotic spindle during injection and cause significantly abnormal pairing of chromosomes when compared with In vitro fertilization (IVF). In this study, we have examined whether ICSI has a higher incidence of aneuploidy when compared with IVF. Material and Methods: A retrospective study was conducted on 36 individuals. Common numbers of chromosome abnormalities were detected using fluorescent in-situ hybridization (FISH). Seven probes were used to detect chromosome X, Y, 13, 16, 18, 21, and 22. Chi-square test was used for statistical analysis and presented as odd ratios with confidence intervals. Results: The age range was 26 through 44 (mean age 35.5) for IVF and 25 through 46 (mean age 35.8) for ICSI. From the 36 egg retrievals, 57 embryos were obtained from nine individuals using IVF and 183 embryos were obtained from 27 individuals using ICSI. For the IVF group, 37 of the 57 examined embryos were abnormal (65%), whereas 128 of 183 examined embryos were abnormal for the ICSI group (69.9%). Among the 57 embryos from the IVF cases, the number of absolute abnormal chromosomes were as follows: XY chromosomes: 4 (12.9%), chromosome 13: 9 (29%), chromosome 16: 7 (22.5%), chromosome 18: 6 (19.3%), chromosome 21: 8 (25.8%), chromosome 22: 10 (32.2%). For the ICSI embryos: X and Y chromosomes: 18 (14%), chromosome 13: 34 (26.5%), chromosome 16: 23 (18%), chromosome 18: 23 (18%), chromosome 21: 26 (20.3%), chromosome 22: 31 (24.2%). The odds ratios for the difference between IVF and ICSI for each chromosome were as follows: XY chromosomes: 1.53 (0.598-3.916), chromosome 13: 0.969 (0.443-2.122), chromosome 16: 0.709 (0.307-1.639), chromosome 18: 1.650 (0.650-4.188), chromosome 21: 0.777 (0.350-1.724), chromosome 22: 0.647 (0.311-1.348). Overall no significant difference between two insemination procedures was seen 0.948 (0.678-1.324). Conclusions: As a result; ICSI does not create a significantly higher aneuploidy number when compared with IVF as examined by FISH analysis of seven chromosome pairs.en_US
dc.identifier.doi10.4103/1119-3077.208959
dc.identifier.endpage658en_US
dc.identifier.issn1119-3077
dc.identifier.issue6en_US
dc.identifier.pmid28656917en_US
dc.identifier.scopus2-s2.0-85028306980en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage652en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.208959
dc.identifier.urihttps://hdl.handle.net/11616/97946
dc.identifier.volume20en_US
dc.identifier.wosWOS:000407813400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneuploidyen_US
dc.subjectinfertilityen_US
dc.subjectICSIen_US
dc.subjectIVFen_US
dc.subjectfluorescent in-situ hybridizationen_US
dc.titleTo compare aneuploidy rates between ICSI and IVF Casesen_US
dc.typeArticleen_US

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