Erythrocyte and plasma superoxide dismutase activities in acute appendicitis

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dc.authorscopusid6701569132
dc.authorscopusid6603551686
dc.authorscopusid6603918063
dc.authorscopusid57018844500
dc.authorscopusid6506849357
dc.authorscopusid6506108123
dc.authorscopusid57196653167
dc.contributor.authorKoltuksuz U.
dc.contributor.authorUz E.
dc.contributor.authorGursoy H.
dc.contributor.authorDemircan M.
dc.contributor.authorAydinc M.
dc.contributor.authorMutus M.
dc.contributor.authorCetin S.
dc.date.accessioned2024-08-04T19:59:42Z
dc.date.available2024-08-04T19:59:42Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough the role of oxygen free radicals in many inflammatory diseases has been well known, it has not been thoroughly investigated in the inflammatory diseases, of the abdomen. In order to investigate the possible role of oxygen free radicals in the mechanism of progression following the onset of inflammation, blood samples from 18 patients diagnosed as acute appendicitis and 10 healthy children as controls were collected. After plasma and erythrocytes of the blood samples were separated, superoxide dismutase (SOD) activities were measured in these compartments. Additionally, the patients with appendicitis were divided into perforated (n=8), and nonperforated (n=10) subgroups, according to intraoperative examination findings and histopathological classification. SOD activities were compared statistically between these two groups, and the control group. A significant difference in SOD activity between perforated and nonperforated appendicitis in both plasma and erythrocyte was observed (plasma: 4.2±1.7 and 2.0±0.7 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1104.2±225.1 U/grHb, p<0.05). The difference between the nonperforated group and control group was not significant, whereas there was a significant difference between the perforated and control groups (plasma: 4.2±1.7 and 2.6±0.9 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1148.8±152.2 U/grHb, p<0.05). According to these results, we may speculate that free oxygen radicals released from polymorphonuclear leucocytes following an inflammatory condition may play an important role in the progression of acute appendicitis with the contribution of some other possible factors.en_US
dc.identifier.endpage22en_US
dc.identifier.issn1016-5142
dc.identifier.issue1-3en_US
dc.identifier.scopus2-s2.0-0032470602en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/11616/90832
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofPediatrik Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute appendicitisen_US
dc.subjectOxygen free radicalsen_US
dc.subjectSuperoxide dismutase activityen_US
dc.titleErythrocyte and plasma superoxide dismutase activities in acute appendicitisen_US
dc.title.alternativeAkut apandisitte plazma ve eritrosit superoksit dismutaz aktivitelerien_US
dc.typeArticleen_US

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