Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridKaloğlu, Murat/0000-0002-2770-5532
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidKaloğlu, Murat/AAA-3956-2021
dc.contributor.authorKaloglu, Murat
dc.contributor.authorKaloglu, Nazan
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGunal, Selami
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:42:31Z
dc.date.available2024-08-04T20:42:31Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNovel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors, these NHC precursors were metallated with Ag2O in dichloromethane at room temperature to give novel silver (I)-NHC complexes. Structures of these benzimidazolium salts and silver(I)-NHC complexes were characterized on the basis of elemental analysis, H-1 NMR, C-13 NMR, IR and LC-MS spectroscopic techniques. A series of benzimidazolium salts and silver(I)-NHC complexes were tested against standard bacterial strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungal strains: Candida albicans and Candida tropicalis. The results showed that benzimidazolium salts inhibited the growth of all bacteria and fungi strains and all silver(I)-NHC complexes performed good activities against different microorganisms. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [TBAG (108T411)]en_US
dc.description.sponsorshipThis work was financially supported by the Technological and Scientific Research Council of Turkey TUBITAK [TBAG (108T411)].en_US
dc.identifier.doi10.1016/j.bmc.2016.06.004
dc.identifier.endpage3656en_US
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue16en_US
dc.identifier.pmid27301680en_US
dc.identifier.scopus2-s2.0-84978245394en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3649en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2016.06.004
dc.identifier.urihttps://hdl.handle.net/11616/97410
dc.identifier.volume24en_US
dc.identifier.wosWOS:000380515700036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectSilver(I)-NHC complexesen_US
dc.subjectBenzimidazolium saltsen_US
dc.subjectMetallopharmaceuticals in vitroen_US
dc.subjectantimicrobial activityen_US
dc.titleNovel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agentsen_US
dc.typeArticleen_US

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