Opportunistic Bone Health Assessment Using Contrast-Enhanced Abdominal CT: A DXA-Referenced Analysis in Liver Transplant Recipients

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dc.contributor.authorDag, Nurullah
dc.contributor.authorUlubaba, Hilal Er
dc.contributor.authorTasolar, Sevgi
dc.contributor.authorCandur, Mehmet
dc.contributor.authorAkbulut, Sami
dc.date.accessioned2026-04-04T13:31:09Z
dc.date.available2026-04-04T13:31:09Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: This study aimed to investigate the relationship between computed tomography (CT)-derived Hounsfield Unit (HU) measurements and dual-energy X-ray absorptiometry (DXA) and to evaluate the feasibility of using contrast-enhanced abdominal CT as a complementary tool in the assessment of bone health in liver transplant recipients. Methods: This retrospective descriptive and analytical study included adult liver transplant recipients who underwent both contrast-enhanced abdominal CT and DXA within a three-month interval. HU measurements were obtained from sagittal and axial reformatted images at the lumbar spine (L1-L4) and femoral neck. All CT examinations were performed using a standardized venous-phase protocol. DXA-derived T-scores from the lumbar spine and femur served as the reference standard. Correlation analyses and receiver operating characteristic (ROC) curves were used to evaluate associations between HU values and BMD, as well as the diagnostic performance of HU in identifying low bone density. Results: A total of 259 recipients (mean age 55.7 +/- 14.4 years; 62.9% male) were included. Based on lumbar spine DXA, 17.8% had normal BMD, 36.7% were osteopenic, and 45.5% were osteoporotic. CT-derived HU values at both the lumbar spine and femoral neck were significantly lower in patients with reduced BMD and showed a graded decline across worsening DXA categories. HU values demonstrated positive correlations with corresponding T-scores. Diagnostic performance for detecting osteoporosis was fair, with AUCs of 0.700 (sagittal), 0.698 (axial), and 0.751 (femoral). Conclusion: Contrast-enhanced abdominal CT provides useful ancillary information for opportunistic bone health assessment. CT-derived HU values offer a rapid and cost-effective complementary tool but should not replace DXA in the diagnostic evaluation of osteoporosis
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [2025/4387]
dc.description.sponsorshipThe research was financially supported by the Inonu University Scientific Research Projects Coordination Unit (Grant No: 2025/4387).
dc.identifier.doi10.3390/diagnostics16010029
dc.identifier.issn2075-4418
dc.identifier.issue1
dc.identifier.orcid0000-0003-2124-4525
dc.identifier.orcid0000-0002-9342-0244
dc.identifier.orcid0000-0002-9836-6814
dc.identifier.orcid0000-0002-6864-7711
dc.identifier.pmid41515524
dc.identifier.scopus2-s2.0-105027261614
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/diagnostics16010029
dc.identifier.urihttps://hdl.handle.net/11616/108605
dc.identifier.volume16
dc.identifier.wosWOS:001657646400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectliver transplantation
dc.subjectbone health
dc.subjectcomputed tomography
dc.subjectHounsfield unit
dc.subjectdual-energy X-ray absorptiometry
dc.titleOpportunistic Bone Health Assessment Using Contrast-Enhanced Abdominal CT: A DXA-Referenced Analysis in Liver Transplant Recipients
dc.typeArticle

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