Age-related changes in the incidence of pineal gland calcification in Turkey: A prospective multicenter CT study

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dc.authorscopusid8876970800
dc.authorscopusid6603854521
dc.authorscopusid6603415997
dc.authorscopusid7801510343
dc.authorscopusid6603218574
dc.authorscopusid23102238700
dc.authorscopusid23467980700
dc.contributor.authorTurgut A.T.
dc.contributor.authorKarakaş H.M.
dc.contributor.authorÖzsunar Y.
dc.contributor.authorAltin L.
dc.contributor.authorÇeken K.
dc.contributor.authorAlicio?lu B.
dc.contributor.authorSönmez I.
dc.date.accessioned2024-08-04T19:59:33Z
dc.date.available2024-08-04T19:59:33Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe goal of this cross-sectional observational study was to determine the incidence of pineal gland calcification (PGC), to investigate the interaction of PGC and aging, and to compare the incidence of PGC among the populations living in Turkey. In a prospective study the rate of PGC on CT scans of 1376 individuals in six referral centers from different regions of Turkey was investigated, with emphasis on effects of climatological parameters and aging on PGC. It was found that the incidence of PGC increased rapidly after first decade and the increase remains gradual thereafter, higher in males than in females for all age groups. There was a significant difference for incidence and degree of PGC between different clinics and between both sexes (p < 0.001). In addition, there was a significant difference for the degree of PGC between the clinics in low altitude group and those in high altitude group (p < 0.001 for each). Logistic regression analysis revealed that age, sex, altitude and intensity of sunlight exposure significantly affected the risk of PGC (odds ratios (OR) 1.335, 95% confidence intervals (CI) 1.261-1.414, p < 0.001; OR 1.900, 95% CI 1.486-2.428, p < 0.001; OR 0.715, 95% CI 0.517-0.990, p < 0.05; OR 0.997, 95% CI 0.994-0.999, p < 0.01, respectively). Furthermore, by multiple linear regression analysis, high altitude and increased intensity of sunlight exposure were found to affect the degree of PGC (? = 0.003, p < 0.001). It is concluded that there is a close relationship between PGC and the aforementioned parameters, supporting a link between the development of PGC and these. This study provides some reference data for new clinical studies on the putative role of pineal gland in future. © 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.pathophys.2008.02.001
dc.identifier.endpage48en_US
dc.identifier.issn0928-4680
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-42749091120en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1016/j.pathophys.2008.02.001
dc.identifier.urihttps://hdl.handle.net/11616/90725
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPathophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcificationen_US
dc.subjectComputed tomographyen_US
dc.subjectPineal glanden_US
dc.subjectTurkeyen_US
dc.titleAge-related changes in the incidence of pineal gland calcification in Turkey: A prospective multicenter CT studyen_US
dc.typeArticleen_US

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