Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice

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dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridArmutcu, Ferah/0000-0002-3218-9480;
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.contributor.authorIlhan, A
dc.contributor.authorGurel, A
dc.contributor.authorArmutcu, F
dc.contributor.authorKamisli, S
dc.contributor.authorIraz, M
dc.date.accessioned2024-08-04T20:14:56Z
dc.date.available2024-08-04T20:14:56Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNigella sativa oil (NSO), a herbaceous plant, has been used for thousands of years for culinary and medical purposes. This study aimed to investigate the anticonvulsant and antioxidant activities of NSO on pentylenetetrazol (PTZ) kindling seizures in mice. Nigella sativa oil was tested for its ability (i) to suppress the convulsive and lethal effects of PTZ in kindled mice (anti-epileptogenic effect), (ii) to attenuate the PTZ-induced oxidative injury in the brain tissue (antioxidant effect) when given as a pretreatment prior to each PTZ injection during kindling acquisition. Valproate, a major antiepileptic drug, was also tested for comparison. Both substances studied significantly decreased oxidative injury in the mouse brain tissue in comparison with the PTZ-kindling group. Nigella sativa oil was found to be the most effective in preventing PTZ-induced seizures relative to valproate. Nigella sativa oil showed anti-epileptogenic properties as it reduced the sensitivity of kindled mice to the convulsive and lethal effects of PTZ; valproate was ineffective in preventing development of any of these effects. The data obtained support the hypothesis that neuroprotective action of NSO may correlate with its ability to inhibit not only excessive reactive oxygen species (ROS) formation but also seizure generation. (c) 2005 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.neuropharm.2005.04.004
dc.identifier.endpage464en_US
dc.identifier.issn0028-3908
dc.identifier.issue4en_US
dc.identifier.pmid15913671en_US
dc.identifier.scopus2-s2.0-23844532345en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage456en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2005.04.004
dc.identifier.urihttps://hdl.handle.net/11616/94066
dc.identifier.volume49en_US
dc.identifier.wosWOS:000231778000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNeuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoxidative injuryen_US
dc.subjectconvulsionen_US
dc.subjectNigella sativa oilen_US
dc.subjectvalproateen_US
dc.subjectkindlingen_US
dc.titleAntiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in miceen_US
dc.typeArticleen_US

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