Fabrication, thermal and in vitro behaviors of ciprofloxacin loaded ?-cyclodextrin-PEG based polyurethanes as potential biomaterial for wound dressing applications

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.contributor.authorKantarcioglu, Melike
dc.contributor.authorTunc, Merve Goksin Karaaslan
dc.contributor.authorGurses, Canbolat
dc.contributor.authorAtes, Burhan
dc.contributor.authorKoytepe, Suleyman
dc.date.accessioned2024-08-04T20:51:46Z
dc.date.available2024-08-04T20:51:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAntibacterial polyurethanes as wound-dressing material with high biocompatibility and thermal stability were developed from polyethylene glycol-200 (PEG200), 4,4'-methylenebis(cyclohexyl isocyanate) (HMDI) and beta-cyclodextrin (beta CD). beta CD was preferred in this material because of providing biocompatibility and supporting the absorption/desorption characteristics of ciprofloxacin due to its hydrophobic gap. The beta-cyclodextrin-PEG based polyurethane structures (PU-200-beta CDs) was synthesized with different beta-cyclodextrin:PEG:HMDI ratios. PU-200-beta CDs were characterized by FTIR spectroscopy, thermal analysis, SEM, and water contact angle techniques. The biocompatibility property of polyurethane materials was determined according to the indirect cytotoxicity assay results and the PU-200-beta CDs exhibited cell viability ranging from, 83.04 +/- 7.28% to 99.73 +/- 10.3% against L-929 cells. The hydrolytic degradability test was applied to the highest biocompatible PU-200-beta CD3 structure. The mass loss of PU-200-beta CD3 was determined 4.75 +/- 0.86% at the end of the 28-day. Antibacterial properties of ciprofloxacin doped PU-200-beta CD3 were investigated using Escherichia coli and Bacillus subtilis. The ideal polyurethane structure was selected according to its biocompatibility and antibacterial properties. This polyurethane structure was converted into wound dressing material via electrospinning technique. The obtained dressing material showed mechanical stable fiber structure. Therefore, prepared beta-cyclodextrin-PEG-based polyurethane structure can be suitable for the production of wound-dressing material due to its good ciprofloxacin release properties, high stability and biocompatibility.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [BAP-2016/17]en_US
dc.description.sponsorshipThis study was supported financially by Inonu University Scientific Research Projects Unit with project BAP-2016/17.en_US
dc.identifier.doi10.1080/10601325.2022.2048954
dc.identifier.endpage345en_US
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85126369174en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1080/10601325.2022.2048954
dc.identifier.urihttps://hdl.handle.net/11616/100534
dc.identifier.volume59en_US
dc.identifier.wosWOS:000767110800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyurethaneen_US
dc.subjectbeta-cyclodextrinen_US
dc.subjectciprofloxacinen_US
dc.subjectantibacterial filmen_US
dc.subjectbiocompatibilityen_US
dc.titleFabrication, thermal and in vitro behaviors of ciprofloxacin loaded ?-cyclodextrin-PEG based polyurethanes as potential biomaterial for wound dressing applicationsen_US
dc.typeArticleen_US

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