A new PEPPSI type N-heterocyclic carbene palladium(II) complexes and its efficiency as a catalyst for Mizoroki-Heck cross-coupling reactions in water : Synthesis, Characterization and their antimicrobial and Cytotoxic activities

Basit Öğe Kaydı
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorMnasri, Aziza
dc.contributor.authorAl-Ayed, Abdullah Sulaiman
dc.contributor.authorOzdeir, Ismail
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorNaceur, Hamdi
dc.date.accessioned2024-08-04T20:49:23Z
dc.date.available2024-08-04T20:49:23Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of novel benzimidazolium salts 2 and their new air and moisture stable PEPPSI type N-heterocyclic carbene palladium(II) complexes (PEPPSI: pyridine-enhanced pre-catalyst preparation, stabilisation, and initiation), were synthesized and characterized by means of H-1 and C-13{1H} NMR, FTIR spectroscopic methods and elemental analysis was employed to catalyze the Mizoroki-Heck cross-coupling reactions of aryl bromides with styrene in water. To the best of our knowledge, this is the first report where a Pd-PEPPSI catalyst was successfully employed in aqueous-phase Mizoroki-Heck reaction. Good to excellent yields of cross-coupling products were obtained with a range of representative aryl bromides under relatively mild conditions. Moreever the antimicrobial activity of the PEPPSI type N-heterocyclic carbene palladium(II) complexes 3a-e varies with the nature of the ligands. Also, the IC50 values of both, complexes (3a-e) have been determined. In addition, the new PEPPSI type N-heterocyclic carbene palladium(II) complexes were screened for their cytotoxic activities. Complex 3b exhibited the highest antitumor effect with IC50 values 0.63 mu g/mL and against MCF-7. (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund [IU-BAP: FBG-2019-1594]en_US
dc.description.sponsorshipThis study was supported by the Inonu University Research Fund (IU-BAP: FBG-2019-1594).en_US
dc.identifier.doi10.1016/j.molstruc.2021.130204
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85102274479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.130204
dc.identifier.urihttps://hdl.handle.net/11616/99809
dc.identifier.volume1234en_US
dc.identifier.wosWOS:000637751900013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazolium salten_US
dc.subjectPalladium catalysisen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectCytotoxic activityen_US
dc.subjectAntimicrobial activityen_US
dc.titleA new PEPPSI type N-heterocyclic carbene palladium(II) complexes and its efficiency as a catalyst for Mizoroki-Heck cross-coupling reactions in water : Synthesis, Characterization and their antimicrobial and Cytotoxic activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu