Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)

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dc.authoridZorkun, Cafer/0000-0002-6726-0478
dc.authoridDelibasi, Tuncay/0000-0002-5780-8209
dc.authorwosidDinckal, Mustafa Hakan/AAB-2916-2021
dc.authorwosidZorkun, Cafer/Q-1247-2019
dc.authorwosidFak, ali Serdar/AAC-8042-2020
dc.authorwosidDelibasi, Tuncay/ABE-5351-2021
dc.contributor.authorTokgozoglu, Lale
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorAltindag, Rojhat
dc.contributor.authorCeyhan, Ceyhun
dc.contributor.authorYeter, Ekrem
dc.contributor.authorOzturk, Cihan
dc.contributor.authorBayram, Fahri
dc.date.accessioned2024-08-04T20:41:42Z
dc.date.available2024-08-04T20:41:42Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia. Methods: A total of 532 patients (age mean+/-SD: 57.4+/-11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinuation were included in this national cross-sectional noninterventional observational study. Data on socio-demographic characteristics of patients, cardiovascular risk factors, past treatment with and discontinuation of statin treatment were collected in one visit. Results: Mean+/-SD duration of hypercholesterolemia was 4.9+/-4.2 years at time of discontinuation of statin treatment. Statin treatment was initiated by cardiologists in the majority of cases (55.8%), whereas discontinuation of statin treatment was decided by patients in the majority of cases (73.7%), with patients with higher (at least secondary education, 80.4%) more likely than those with lower (only primary education, 69.7%) to decide to discontinue treatment (p=0.022). Negative information about statin treatment disseminated by TV programs-mostly regarding coverage of hepatic (38.0%), renal (33.8%), and muscular (32.9%) side effects (32.9%)-was the most common reason for treatment discontinuation. Conclusion: The decision to discontinue statin treatment was made at the patient's discretion in 74% of cases, with higher likelihood of patients with higher educational status deciding to discontinue treatment and switch to non-drug lipid-lowering alternatives. Cardiologists were the physicians most frequently responsible for the initiation of the statin treatment; coverage of several non-lifethreatening statin side effects by TV programs and patients' lack of information regarding high cholesterol and related risks were the leading factors predisposing to treatment discontinuation.en_US
dc.description.sponsorshipAstraZeneca Turkiyeen_US
dc.description.sponsorshipThe study was funded by a grant from AstraZeneca Turkiye.en_US
dc.identifier.doi10.5543/tkda.2015.47041
dc.identifier.endpage64en_US
dc.identifier.issn1016-5169
dc.identifier.issue1en_US
dc.identifier.pmid26875131en_US
dc.identifier.scopus2-s2.0-84964461987en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2015.47041
dc.identifier.urihttps://hdl.handle.net/11616/97291
dc.identifier.volume44en_US
dc.identifier.wosWOS:000371267200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectpatient characteristicsen_US
dc.subjectpredisposing factorsen_US
dc.subjectstatin discontinuationen_US
dc.subjectTurkeyen_US
dc.titlePatient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)en_US
dc.typeArticleen_US

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