Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives

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dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidGençer, Nahit/AAG-4507-2019
dc.authorwosidGençer, Nahit/HHD-1544-2022
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorAlici, Bulent
dc.contributor.authorCetinkaya, Engin
dc.contributor.authorBilen, Cigdem
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2024-08-04T20:39:49Z
dc.date.available2024-08-04T20:39:49Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstract1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, H-1 NMR, C-13 NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzo[d]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM).en_US
dc.identifier.doi10.1134/S1068162014040049
dc.identifier.endpage466en_US
dc.identifier.issn1068-1620
dc.identifier.issn1608-330X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84905166327en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1134/S1068162014040049
dc.identifier.urihttps://hdl.handle.net/11616/96527
dc.identifier.volume40en_US
dc.identifier.wosWOS:000339925100013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal of Bioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbenzimidazoleen_US
dc.subjectenzymatic browningen_US
dc.subjecttyrosinase inhibitorsen_US
dc.titleSynthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivativesen_US
dc.typeArticleen_US

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