Investigation of age, sex and menstrual stage variation in human cerumen lipid composition by high performance thin layer chromatography

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dc.authoridMiman, Murat Cem/0000-0002-2139-9239;
dc.authorwosidMiman, Murat Cem/AAZ-4873-2020
dc.authorwosidGüldür, Tayfun/AAA-7088-2021
dc.contributor.authorKocer, M.
dc.contributor.authorGuldur, T.
dc.contributor.authorAkarcay, M.
dc.contributor.authorMiman, M. C.
dc.contributor.authorBeker, G.
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The objective of the study was to correlate quantitative changes in the lipid composition of human cerumen with changes in age, sex and menstrual cycle stage. Design: Cerumen samples were collected from the external ear canal and analysed using sequential, one dimensional, high performance thin layer chromatography. Subjects: The following age groups of both sexes were investigated: one to 10 years, 11-18 years; 19-40 years; and 40 years and over. Additionally, cerumen samples from subjects in three stages of the menstrual cycle were compared. Results: In the cerumen samples, the peak values for wax ester and cholesterol occured between the ages of one and 10 years for both sexes. However, squalene and triglyceride content reached maximum levels at puberty. Men aged 19-40 years had a significantly greater percentage of cerumen lipid squalene content than women from the same age group; however, their cholesterol content was found to be lower. Regarding the various menstrual cycle stages, cerumen samples taken at the follicular stage from women aged 19-40 years had a significantly lower free fatty acids content, and higher cholesterol and squalene levels, compared with samples taken in the luteal or menstrual stages. Conclusion: The proportions of the lipid constituents of cerumen varied with age, sex and menstrual stage. In cerumen, the main lipid constituent stimulated at puberty appears to be squalene, not wax esters as reported for sebum. The relevance of lipid constituents to cerumen's protective role is discussed.en_US
dc.description.sponsorshipInonu University (Malatya, Turkey)en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Unit of Inonu University (Malatya, Turkey) (Project 2004 Guz-3).en_US
dc.identifier.doi10.1017/S0022215107000783
dc.identifier.endpage886en_US
dc.identifier.issn0022-2151
dc.identifier.issue9en_US
dc.identifier.pmid17931445en_US
dc.identifier.scopus2-s2.0-50049134688en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage881en_US
dc.identifier.urihttps://doi.org/10.1017/S0022215107000783
dc.identifier.urihttps://hdl.handle.net/11616/94633
dc.identifier.volume122en_US
dc.identifier.wosWOS:000259331000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal of Laryngology and Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcerumenen_US
dc.subjectexternal auditory canalen_US
dc.subjectlipidsen_US
dc.subjectmenstrual cycleen_US
dc.subjectotitis externaen_US
dc.titleInvestigation of age, sex and menstrual stage variation in human cerumen lipid composition by high performance thin layer chromatographyen_US
dc.typeArticleen_US

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