A comparison of the efficacy and tolerability of topical agents used in facial Demodex treatment

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dc.authorwosidSarac, Gulbahar/ABF-3119-2020
dc.contributor.authorSarac, Gulbahar
dc.date.accessioned2024-08-04T20:45:56Z
dc.date.available2024-08-04T20:45:56Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Demodex spp. is the most common ectoparasite in humans. This parasite is believed to play a role in the etiology of many dermatological and ocular disorders. Aim: The aim of this study was to compare the efficacy and tolerability of the sulfur-sodium sulfacetamide combination, crotamiton, and permethrin, which are three topical agents commonly used in Demodex treatment. Methods: A total of 28 patients with primary demodicosis and 44 patients with Rosacea + Demodex were included in the study. The pretreatment and post-treatment Demodex spp. counts, patient satisfaction, and erythema decrease rates were compared. Results: Analysis of the efficacy of these topical agents on Demodex revealed that all three significantly decreased the number of parasites. The patient satisfaction was higher in the sodium acetamide group than the 10% crotamiton and 5% permethrin groups, and clinical evaluation (erythema/ papulopustules and white plugs) was better in the sodium acetamide group than the other groups but no statistically significant difference was found in terms of patient satisfaction and clinical evaluation. Conclusion: The sulfur-sodium combination, crotamiton, and permethrin are the three agents commonly used in the treatment of Demodex spp. and all significantly decreased the Demodex count. The three agents were similar in terms of tolerability. Our study needs to be supported with others on larger patient series.en_US
dc.identifier.doi10.1111/jocd.12986
dc.identifier.endpage1787en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue6en_US
dc.identifier.pmid31066486en_US
dc.identifier.scopus2-s2.0-85065541693en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1784en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.12986
dc.identifier.urihttps://hdl.handle.net/11616/98789
dc.identifier.volume18en_US
dc.identifier.wosWOS:000518545000034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcrotamitonen_US
dc.subjectfacial Demodexen_US
dc.subjectpermethrinen_US
dc.subjectsulfur-sodium sulfacetamide combinationen_US
dc.titleA comparison of the efficacy and tolerability of topical agents used in facial Demodex treatmenten_US
dc.typeArticleen_US

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