New morpholine-liganded palladium(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and DNA-binding studies

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dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridAktaş, Aydın/0000-0001-8496-6782;
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.contributor.authorTurker, Ferhat
dc.contributor.authorGurses, Canbolat
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorAktas, Aydin
dc.contributor.authorAtes, Burhan
dc.contributor.authorGok, Yetkin
dc.date.accessioned2024-08-04T20:46:50Z
dc.date.available2024-08-04T20:46:50Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of the morpholine-liganded palladium(II) complexes (1a-e) bearing N-heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using H-1 NMR, C-13 NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Single-crystal X-ray diffraction was used to determine the structure of a derivative. The DNA-binding studies of the new (NHC)Pd(II)morpholine complexes were examined using the pBR322 plasmid. The 2,4,6-trimethylbenzyl derivative compound has the most DNA binding activity. In addition, for the 3-methylbenzyl derivative compound, oxidation effects were observed at concentrations higher than 100 mu g/ml. Also, the molecular and crystal structures of the complex 3-methylbenzyl derivative compound were recorded by using a single-crystal X-ray diffraction method.en_US
dc.description.sponsorshipInonu University Research Fund [FYL-2019-1446]; Dokuz Eylul University [KB.FEN.13]en_US
dc.description.sponsorshipInonu University Research Fund, Grant/Award Number: FYL-2019-1446; Dokuz Eylul University, Grant/Award Number: 2010.KB.FEN.13en_US
dc.identifier.doi10.1002/ardp.201900187
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue12en_US
dc.identifier.pmid31583763en_US
dc.identifier.scopus2-s2.0-85073960768en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.201900187
dc.identifier.urihttps://hdl.handle.net/11616/98991
dc.identifier.volume352en_US
dc.identifier.wosWOS:000491199200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA bindingen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectstructure elucidationen_US
dc.subjectsubstituent effecten_US
dc.subjectsynthesisen_US
dc.titleNew morpholine-liganded palladium(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and DNA-binding studiesen_US
dc.typeArticleen_US

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