Nanoneedle-Based Transdermal Gene Delivery: A Minimally Invasive Strategy for Gene Therapy

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dc.contributor.authorAkbuga, Fatma Julide
dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorSalva, Emine
dc.date.accessioned2026-04-04T13:31:08Z
dc.date.available2026-04-04T13:31:08Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractTransdermal drug delivery systems have recently been explored as an alternative to oral systems, which have many challenges. Due to the limitations of first-generation transdermal systems, second- and third-generation systems have been developed, among which microneedles have been the most remarkable products. Building on the advancements of nanotechnology, nanoneedles have recently been developed. Gene therapy molecules-such as DNA, RNA, siRNA, miRNA, and other nucleic acids-are typically delivered using viral or chemical carriers, but these methods face several challenges. In this context, nanoneedles offer a promising and efficient solution for delivering these large molecules. Nanoneedles are a biocompatible and reliable physical method for gene delivery, enabling transdermal administration by penetrating the skin barrier and delivering nucleic acids directly into cells. Their ability to penetrate cellular barriers with minimal invasiveness makes them advantageous for delivering genetic materials. This review will focus on the potential applications of nanoneedles in pharmaceutical contexts, especially in gene therapy. In addition, information on the properties, structure, and fabrication of nanoneedles is also provided.
dc.identifier.doi10.3390/ijms26136235
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue13
dc.identifier.orcid0000-0002-1159-5850
dc.identifier.orcid0000-0002-1693-9579
dc.identifier.orcid0000-0001-9290-2404
dc.identifier.pmid40650006
dc.identifier.scopus2-s2.0-105010309408
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms26136235
dc.identifier.urihttps://hdl.handle.net/11616/108576
dc.identifier.volume26
dc.identifier.wosWOS:001526389700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectnanoneedle
dc.subjectgene delivery
dc.subjecttransdermal
dc.subjectsiRNA
dc.subjectDNA
dc.subjectCRISPR
dc.titleNanoneedle-Based Transdermal Gene Delivery: A Minimally Invasive Strategy for Gene Therapy
dc.typeReview

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