Effects of fentanyl on the incidence of emergence agitation in children receiving desflurane or sevoflurane anaesthesia

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dc.authoridcicek, muslum/0000-0001-9187-8342
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidcicek, muslum/P-5252-2019
dc.authorwosidcicek, muslum/AGX-0585-2022
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorDemirbilek, S
dc.contributor.authorTogal, T
dc.contributor.authorCicek, M
dc.contributor.authorAslan, U
dc.contributor.authorSizanli, E
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:15:16Z
dc.date.available2024-08-04T20:15:16Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: In children, emergence agitation frequently complicates sevoflurane and desflurane anaesthesia. The effect of intravenous fentanyl 2.5 mug kg(-1) was examined on the incidence of emergence agitation in children who received desflurane or sevoflurane after midazolam premedication and intravenous thiopental induction. Methods: One hundred and twenty children (2-7 yr) undergoing adenoidectomy or tonsillectomy, or both, were studied. All children were premedicated orally with midazolam 0.5 mg kg(-1). After intravenous induction with thiopental and atracurium to facilitate endotracheal intubation, patients were randomly assigned to one of four groups: Patients in Groups I and 3 received physiological saline solution, whereas patients in Groups 2 and 4 received intravenous fentanyl 2.5 mug kg(-1) during induction. Anaesthesia was maintained with sevoflurane in Groups I and 2 and with desflurane in Groups 3 and 4. After discontinuation of the volatile anaesthetic, the times to tracheal extubation and response to verbal stimuli (emergence time), and emergence behaviours were recorded. Results: The time to tracheal extubation was significantly shorter in Groups 3 (5.2 +/- 1.7 min) and 4 (6.4 +/- 2.1 min) than in Groups 1 (8.1 +/- 2.1 min) (P = 0.0001 and 0.006, respectively) and 2 (8.8 +/- 1.9 min) (P = 0.0001). The emergence time was significantly shorter in Group 3 (10.0 +/- 3.9 min) than in Groups 1 (13.8 +/- 4.9 min) (P = 0.017) and 2 (14.9 +/- 4.1 min) (P = 0.003). The incidence rate of severe agitation was 13% in Groups 1 and 3, and 7 and 10% in Groups 2 and 4, respectively (P > 0.05). Conclusions: After midazolam premedication and intravenous induction of anaesthesia with thiopental, administration of intravenous fentanyl 2.5 mug kg(-1) did not provide any clinically significant benefit on emergence agitation in children who receive sevoflurane or desflurane anaesthesia.en_US
dc.identifier.doi10.1017/S0265021504007069
dc.identifier.endpage542en_US
dc.identifier.issn0265-0215
dc.identifier.issue7en_US
dc.identifier.pmid15318465en_US
dc.identifier.scopus2-s2.0-3342920931en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021504007069
dc.identifier.urihttps://hdl.handle.net/11616/94283
dc.identifier.volume21en_US
dc.identifier.wosWOS:000222984600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGreenwich Medical Media Ltden_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanaesthetics, inhalation, desflurane, sevofluraneen_US
dc.subjectchildren, midazolam, premedicationen_US
dc.subjectcomplications, emergence agitationen_US
dc.titleEffects of fentanyl on the incidence of emergence agitation in children receiving desflurane or sevoflurane anaesthesiaen_US
dc.typeArticleen_US

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