Molecular analysis and ceftazidime-avibactam susceptibilities of carbapenem-resistant Klebsiella pneumoniae: Seven year experience from blood cultures of liver transplant recipients in a university hospital

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dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorBayindir, Yasar
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorKarabulut, Ertugrul
dc.contributor.authorDuman, Yucel
dc.contributor.authorOtlu, Baris
dc.date.accessioned2026-04-04T13:35:09Z
dc.date.available2026-04-04T13:35:09Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection is a major cause of mortality in liver transplantation (LT) recipients. Methods: We aimed to elucidate the molecular mechanisms of carbapenem resistance among CRKP strains and determine ceftazidime-avibactam (CZA) in vitro susceptibility in high-risk patient populations, such as LT recipients. Results: Of the 127 LT recipients between January 2016 and 2022, no statistically significant difference was found in the in vitro sensitivity of amikacin, gentamicin, ciprofloxacin, levofloxacin, imipenem, meropenem, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, tigecycline, and colistin in patients with CRKP sepsis who survived and died at 30 days, except for amikacin and meropenem, which was statistically significant at 90 days (p <= 0.05). Of the isolates, 120 (94.4 %) were positive for the modified carbapenem inactivation test. When the carbapenemase genes of 127 CRKP isolates were analyzed, the most common carbapenemase gene was OXA-48 (59.1 %). The presence of OXA-48, OXA-48 + NDM, NDM, IMP, and VIM genes in CRKP isolates showed a statistically significant difference with the CZA susceptibility result (p < 0.05). Conclusions: The presence of the OXA-48 resistance gene in CRKP isolates was closely associated with in vitro susceptibility to CZA, regardless of the diversity of the patient population.
dc.identifier.doi10.1016/j.diagmicrobio.2025.117077
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue1
dc.identifier.orcid0000-0002-5545-3467
dc.identifier.orcid0000-0002-0449-0356
dc.identifier.orcid0000-0002-5433-591X
dc.identifier.pmid40854292
dc.identifier.scopus2-s2.0-105013841004
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2025.117077
dc.identifier.urihttps://hdl.handle.net/11616/109655
dc.identifier.volume114
dc.identifier.wosWOS:001561393200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectCarbapenem-resistant Klebsiella pneumoniae
dc.subjectLiver transplantation
dc.subjectLiving donor
dc.subjectCeftazidime-avibactam
dc.subjectCarbapenemase genes
dc.titleMolecular analysis and ceftazidime-avibactam susceptibilities of carbapenem-resistant Klebsiella pneumoniae: Seven year experience from blood cultures of liver transplant recipients in a university hospital
dc.typeArticle

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