Frequency of Celiac Disease in Attention-deficit/Hyperactivity Disorder

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dc.authoridÖzcan, Özlem/0000-0003-3267-2648
dc.authorwosidÖzcan, Özlem/ABH-9167-2020
dc.contributor.authorGungor, Serdal
dc.contributor.authorCeliloglu, Ozgu Suna
dc.contributor.authorOzcan, Ozlem Ozel
dc.contributor.authorRaif, Sabiha Gungor
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.date.accessioned2024-08-04T20:37:26Z
dc.date.available2024-08-04T20:37:26Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Although it is well known that celiac disease (CD) is associated with neurologic disorders, association with psychiatric problems is not well defined. In this report, we aimed to detect CD prevalence in patients with attention-deficit hyperactivity disorder (ADHD). Methods: A total of 362 patients between the ages 5 and 15 years with the diagnosis of ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnostic criteria and 390 sex- and age-matched healthy children were included in the present study. Serum levels of tissue transglutaminase (tTg) immunoglobulin (Ig) A and IgG were studied in both groups. Serum IgA levels were also studied in patients with positive tTG IgG for the exclusion of selective IgA deficiency. Endoscopic duodenal biopsy was provided in seropositive patients, whose parents approved the procedure. Biopsy samples were evaluated according to Marsh-Oberhuber classification. Results: tTg IgA was positive in 4 patients with ADHD (1.1%). Endoscopic duodenal biopsy was suggestive of CD in one of them (0.27%). tTg IgA was positive in 3 of control group patients (0.8%). Duodenal biopsy of the only patient from control group, who underwent upper gastrointestinal endoscopy, revealed normal intestinal mucosa. Conclusions: The seropositivity rates for CD were found similar in ADHD and control groups. Thus, neither routine screening for CD nor empirical recommendation of gluten-free diet seems necessary in children with ADHD.en_US
dc.identifier.doi10.1097/MPG.0b013e318272b7bc
dc.identifier.endpage214en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue2en_US
dc.identifier.pmid22983377en_US
dc.identifier.scopus2-s2.0-84874535581en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0b013e318272b7bc
dc.identifier.urihttps://hdl.handle.net/11616/95971
dc.identifier.volume56en_US
dc.identifier.wosWOS:000314099600026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectattention-deficit hyperactivity disordersen_US
dc.subjectceliac diseaseen_US
dc.subjectfrequencyen_US
dc.titleFrequency of Celiac Disease in Attention-deficit/Hyperactivity Disorderen_US
dc.typeArticleen_US

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